| Entry |
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| Name |
Carvedilol phosphate (USAN);
Carvedilol phosphate hydrate (JAN);
Coreg CR (TN) |
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| Product |
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| Generic |
CARVEDILOL PHOSPHATE (Amneal Pharmaceuticals of New York LLC), CARVEDILOL PHOSPHATE (Bryant Ranch Prepack), CARVEDILOL PHOSPHATE (Bryant Ranch Prepack), CARVEDILOL PHOSPHATE (Bryant Ranch Prepack), CARVEDILOL PHOSPHATE (Bryant Ranch Prepack), CARVEDILOL PHOSPHATE (Bryant Ranch Prepack), CARVEDILOL PHOSPHATE (Bryant Ranch Prepack), CARVEDILOL PHOSPHATE (Bryant Ranch Prepack), CARVEDILOL PHOSPHATE (Golden State Medical Supply), CARVEDILOL PHOSPHATE (NorthStar RxLLC), CARVEDILOL PHOSPHATE (Sun Pharmaceutical Industries), CARVEDILOL PHOSPHATE (Woodward Pharma Services LLC) |
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| Formula |
(C24H26N2O4)2. 2H3PO4. H2O
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| Exact mass |
1026.3429
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| Mol weight |
1026.9541
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| Structure |
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01642 CYP2C9 substrate
DG01644 CYP2D6 substrate
DG02855 CYP2E1 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Transporter inhibitor
DG01622 ABCB1 inhibitor
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| Remark |
| Product (DG00321): | D00255<JP/US> D03415<US> |
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| Efficacy |
Antihypertensive, alpha1/beta-Adrenergic receptor antagonist |
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| Disease |
|
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565], CYP2C9 [HSA: 1559], CYP3A4 [HSA: 1576], CYP1A2 [HSA: 1544], CYP2E1 [HSA: 1571]
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| Interaction |
Transporter inhibition: ABCB1 [HSA: 5243]
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| Structure map |
| map07215 | alpha-Adrenergic receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AG Alpha and beta blocking agents
C07AG02 Carvedilol
D03415 Carvedilol phosphate (USAN) <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Beta-adrenergic Blocking Agents
Beta-adrenergic Blocking Agents, Other
Carvedilol
D03415 Carvedilol phosphate (USAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG00321 Carvedilol
D03415 Carvedilol phosphate
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG00321 Carvedilol
D03415 Carvedilol phosphate
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00321 Carvedilol
D03415 Carvedilol phosphate
DG01642 CYP2C9 substrate
DG00321 Carvedilol
D03415 Carvedilol phosphate
DG01644 CYP2D6 substrate
DG00321 Carvedilol
D03415 Carvedilol phosphate
DG02855 CYP2E1 substrate
DG00321 Carvedilol
D03415 Carvedilol phosphate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00321 Carvedilol
D03415 Carvedilol phosphate
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00321 Carvedilol
D03415 Carvedilol phosphate
Drug classes [BR:br08332]
Cardiovascular agent
DG03231 Antihypertensive
D03415 Carvedilol phosphate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D03415 Carvedilol phosphate (USAN) <US>
ADRB1
D03415 Carvedilol phosphate (USAN) <US>
ADRB2
D03415 Carvedilol phosphate (USAN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D03415
Drug transporters
D03415
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D03415
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG00321 Carvedilol
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG00321 Carvedilol
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00321 Carvedilol
DG01642 CYP2C9 substrate
DG00321 Carvedilol
DG01644 CYP2D6 substrate
DG00321 Carvedilol
DG02855 CYP2E1 substrate
DG00321 Carvedilol
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00321 Carvedilol
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00321 Carvedilol
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 71
1 P1b P 25.2157 -4.9627
2 O1c O 25.2085 -3.5620
3 O1c O 26.6165 -4.9627
4 O1c O 23.8149 -4.9556
5 O1c O 25.2085 -6.3635
6 O0 O 25.8276 -8.5395
7 C8y C 7.0000 -6.2300
8 C8y C 5.6700 -5.7400
9 C8y C 7.0000 -7.6300
10 C8y C 8.2600 -5.5300
11 C8y C 4.8300 -6.8600
12 C8x C 5.1800 -4.4100
13 N4x N 5.6700 -8.0500
14 C8x C 8.1900 -8.3300
15 C8x C 9.4500 -6.2300
16 O2a O 8.2600 -4.1300
17 C8x C 3.4300 -6.6500
18 C8x C 3.7800 -4.2700
19 C8x C 9.4500 -7.6300
20 C1b C 9.5200 -3.4300
21 C8x C 2.9400 -5.3900
22 C1c C 10.7100 -4.2000
23 C1b C 11.9700 -3.5000
24 O1a O 10.7100 -5.6000
25 N1b N 13.0900 -4.2700
26 C1b C 14.3500 -3.5700
27 C1b C 15.5400 -4.2700
28 O2a O 16.7300 -3.6400
29 C8y C 17.9900 -4.3400
30 C8y C 17.9900 -5.7400
31 C8x C 19.1800 -3.7100
32 C8x C 19.1100 -6.5100
33 O2a O 16.7300 -6.3700
34 C8x C 20.3700 -4.4100
35 C8x C 20.3700 -5.8100
36 C1a C 15.4700 -5.6700
37 P1b P 25.2157 -4.9627
38 O1c O 25.2085 -3.5620
39 O1c O 26.6165 -4.9627
40 O1c O 23.8149 -4.9556
41 O1c O 25.2085 -6.3635
42 C8y C 7.0000 -6.2300
43 C8y C 5.6700 -5.7400
44 C8y C 4.8300 -6.8600
45 C8x C 3.4300 -6.6500
46 C8x C 2.9400 -5.3900
47 C8x C 3.7800 -4.2700
48 C8x C 5.1800 -4.4100
49 N4x N 5.6700 -8.0500
50 C8y C 7.0000 -7.6300
51 C8x C 8.1900 -8.3300
52 C8x C 9.4500 -7.6300
53 C8x C 9.4500 -6.2300
54 C8y C 8.2600 -5.5300
55 O2a O 8.2600 -4.1300
56 C1b C 9.5200 -3.4300
57 C1c C 10.7100 -4.2000
58 C1b C 11.9700 -3.5000
59 N1b N 13.0900 -4.2700
60 C1b C 14.3500 -3.5700
61 C1b C 15.5400 -4.2700
62 O2a O 16.7300 -3.6400
63 C8y C 17.9900 -4.3400
64 C8y C 17.9900 -5.7400
65 C8x C 19.1100 -6.5100
66 C8x C 20.3700 -5.8100
67 C8x C 20.3700 -4.4100
68 C8x C 19.1800 -3.7100
69 O2a O 16.7300 -6.3700
70 C1a C 15.4700 -5.6700
71 O1a O 10.7100 -5.6000
BOND 74
1 1 2 2
2 1 3 1
3 1 4 1
4 1 5 1
5 37 38 2
6 37 39 1
7 37 40 1
8 37 41 1
9 7 8 1
10 7 9 2
11 7 10 1
12 8 11 2
13 8 12 1
14 9 13 1
15 9 14 1
16 10 15 2
17 10 16 1
18 11 17 1
19 12 18 2
20 14 19 2
21 16 20 1
22 17 21 2
23 20 22 1
24 22 23 1
25 22 24 1
26 23 25 1
27 25 26 1
28 26 27 1
29 27 28 1
30 28 29 1
31 29 30 2
32 29 31 1
33 30 32 1
34 30 33 1
35 31 34 2
36 32 35 2
37 33 36 1
38 11 13 1
39 15 19 1
40 18 21 1
41 34 35 1
42 42 43 1
43 42 50 2
44 42 54 1
45 43 44 2
46 43 48 1
47 50 49 1
48 50 51 1
49 54 53 2
50 54 55 1
51 44 45 1
52 48 47 2
53 51 52 2
54 55 56 1
55 45 46 2
56 56 57 1
57 57 58 1
58 57 71 1
59 58 59 1
60 59 60 1
61 60 61 1
62 61 62 1
63 62 63 1
64 63 64 2
65 63 68 1
66 64 65 1
67 64 69 1
68 68 67 2
69 65 66 2
70 69 70 1
71 44 49 1
72 53 52 1
73 47 46 1
74 67 66 1
BRACKET 1 22.5400 -6.9300 22.5400 -2.8700
1 27.7200 -2.8700 27.7200 -6.9300
1 2
ORIGINAL 1 1 2 3 4 5
REPEAT 1 37 38 39 40 41
2 2.8700 -9.2400 2.8700 -2.7300
2 20.8600 -2.7300 20.8600 -9.2400
2 2
ORIGINAL 2 7 8 11 17 21 18 12 13 9 14 19 15 10 16 20 22
2 23 25 26 27 28 29 30 32 35 34 31 33 36 24
REPEAT 2 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57
2 58 59 60 61 62 63 64 65 66 67 68 69 70 71
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