| Entry |
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| Name |
Codeine sulfate (USP);
Codeine sulfate trihydrate;
Codeine sulfate (TN) |
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| Product |
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| Generic |
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| Formula |
(C18H21NO3)2. H2SO4. 3H2O
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| Exact mass |
750.3034
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| Mol weight |
750.8528
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| Structure |
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| Simcomp |
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| Class |
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| Remark |
| Product (DG01076): | D02101<JP> D03580<US> |
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| Efficacy |
Analgesic (narcotic), Antitussive, Opioid receptor agonist |
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| Comment |
Opium alkaloid
Active form of prodrug: Morphine [DR: D08233]
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: UGT2B7 [HSA: 7364], UGT2B4 [HSA: 7363]; CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565]
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| Interaction |
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| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R05 COUGH AND COLD PREPARATIONS
R05D COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
R05DA Opium alkaloids and derivatives
R05DA04 Codeine
D03580 Codeine sulfate (USP) <US>
USP drug classification [BR:br08302]
Analgesics
Opioid Analgesics, Short-acting
Codeine
D03580 Codeine sulfate (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG01076 Codeine
D03580 Codeine sulfate
Analgesic
DG01984 Opioid analgesics
DG01076 Codeine
D03580 Codeine sulfate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01076 Codeine
D03580 Codeine sulfate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01076 Codeine
D03580 Codeine sulfate
DG02924 UGT substrate
DG03189 UGT2B4 substrate
DG01076 Codeine
D03580 Codeine sulfate
DG03190 UGT2B7 substrate
DG01076 Codeine
D03580 Codeine sulfate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D03580 Codeine sulfate (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D03580
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D03580
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG01076 Codeine
Analgesic
DG01984 Opioid analgesics
DG01076 Codeine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01076 Codeine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01076 Codeine
DG02924 UGT substrate
DG03189 UGT2B4 substrate
DG01076 Codeine
DG03190 UGT2B7 substrate
DG01076 Codeine
Prodrugs [br08324.html]
DG01076
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 52
1 O0 O 29.9570 -18.1983
2 C1z C 18.8310 -16.9590
3 C8y C 18.8310 -15.6336
4 C1y C 20.0168 -17.6566
5 C1y C 17.7147 -17.5868
6 C1x C 20.0168 -16.3312
7 C8y C 17.7147 -15.0057
8 C8y C 20.0168 -15.0057
9 C1y C 21.1330 -16.9590
10 C2x C 20.0168 -18.9123
11 O2x O 16.3893 -16.2614
12 C1y C 17.7147 -18.9123
13 C1x C 22.2491 -16.3312
14 C8y C 17.7147 -13.6802
15 C1x C 21.1330 -15.7033
16 C8x C 20.0168 -13.6802
17 N1y N 22.2491 -17.6566
18 C2x C 18.8310 -19.6099
19 O1a O 16.5985 -19.6099
20 C8x C 18.9007 -13.0524
21 O2a O 16.5985 -13.0524
22 C1a C 15.4127 -13.6802
23 C1a C 23.6491 -17.6566
24 S4a S 28.9520 -14.8100
25 O1d O 28.9520 -13.4100
26 O1d O 28.9520 -16.2100
27 O1d O 27.5519 -14.8100
28 O1d O 30.3519 -14.8100
29 O0 O 29.9570 -18.1983
30 O0 O 29.9570 -18.1983
31 C1z C 18.8310 -16.9590
32 C8y C 18.8310 -15.6336
33 C8y C 17.7147 -15.0057
34 C8y C 17.7147 -13.6802
35 C8x C 18.9007 -13.0524
36 C8x C 20.0168 -13.6802
37 C8y C 20.0168 -15.0057
38 C1x C 21.1330 -15.7033
39 C1y C 21.1330 -16.9590
40 C1y C 20.0168 -17.6566
41 C2x C 20.0168 -18.9123
42 C2x C 18.8310 -19.6099
43 C1y C 17.7147 -18.9123
44 C1y C 17.7147 -17.5868
45 O2x O 16.3893 -16.2614
46 O1a O 16.5985 -19.6099
47 N1y N 22.2491 -17.6566
48 C1x C 22.2491 -16.3312
49 C1x C 20.0168 -16.3312
50 C1a C 23.6491 -17.6566
51 O2a O 16.5985 -13.0524
52 C1a C 15.4127 -13.6802
BOND 56
1 24 25 2
2 24 26 2
3 24 27 1
4 24 28 1
5 2 3 1
6 2 4 1
7 2 5 1
8 2 6 1 #Up
9 3 7 2
10 3 8 1
11 4 9 1
12 4 10 1
13 5 11 1 #Down
14 5 12 1
15 6 13 1
16 7 14 1
17 8 15 1
18 8 16 2
19 9 17 1 #Up
20 10 18 2
21 12 19 1 #Down
22 14 20 2
23 14 21 1
24 21 22 1
25 7 11 1
26 9 15 1
27 12 18 1
28 13 17 1
29 16 20 1
30 17 23 1
31 31 32 1
32 31 40 1
33 31 44 1
34 31 49 1 #Up
35 32 33 2
36 32 37 1
37 40 39 1
38 40 41 1
39 44 45 1 #Down
40 44 43 1
41 49 48 1
42 33 34 1
43 37 38 1
44 37 36 2
45 39 47 1 #Up
46 41 42 2
47 43 46 1 #Down
48 34 35 2
49 34 51 1
50 51 52 1
51 33 45 1
52 39 38 1
53 43 42 1
54 48 47 1
55 36 35 1
56 47 50 1
BRACKET 1 27.7200 -18.9700 27.7200 -17.2900
1 30.5200 -17.2900 30.5200 -18.9700
1 3
ORIGINAL 1 1
REPEAT 1 30 31
2 13.4400 -20.3000 13.4400 -12.0400
2 25.0600 -12.0400 25.0600 -20.3000
2 2
ORIGINAL 2 2 3 7 14 20 16 8 15 9 4 10 18 12 5 11 19
2 23 17 13 6 24 21 22
REPEAT 2 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47
2 48 49 50 51 52 53 54
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