KEGG   DRUG: Encainide hydrochloride
Entry
D03991                      Drug                                   
Name
Encainide hydrochloride (USAN)
Formula
C22H28N2O2. HCl
Exact mass
388.1918
Mol weight
388.9309
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01650  Class Ic antiarrhythmic agent
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: C01BC08
Chemical structure group: DG00203
Efficacy
Antiarrhythmic, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07037  Antiarrhythmic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BC Antiarrhythmics, class Ic
     C01BC08 Encainide
      D03991  Encainide hydrochloride (USAN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG00203  Encainide
      D03991  Encainide hydrochloride
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00203  Encainide
    D03991  Encainide hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D03991  Encainide hydrochloride (USAN)
    SCN2A
     D03991  Encainide hydrochloride (USAN)
    SCN3A
     D03991  Encainide hydrochloride (USAN)
    SCN4A
     D03991  Encainide hydrochloride (USAN)
    SCN5A
     D03991  Encainide hydrochloride (USAN)
    SCN8A
     D03991  Encainide hydrochloride (USAN)
    SCN9A
     D03991  Encainide hydrochloride (USAN)
    SCN10A
     D03991  Encainide hydrochloride (USAN)
    SCN11A
     D03991  Encainide hydrochloride (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D03991
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG00203  Encainide
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00203  Encainide
Other DBs
CAS: 66794-74-9
PubChem: 17397996
ChEBI: 59880
LigandBox: D03991
NIKKAJI: J532.862D
LinkDB
KCF data

ATOM        27
            1   X   Cl   41.7199  -19.3899
            2   C8y C    32.6900  -19.6700
            3   C8y C    33.8800  -18.9700
            4   N1b N    31.5000  -18.9700
            5   C8x C    32.6900  -21.0700
            6   C1b C    33.8800  -17.5700
            7   C8x C    35.1400  -19.6700
            8   C5a C    30.2400  -19.6700
            9   C8x C    33.8800  -21.7700
            10  C1b C    35.1400  -16.8700
            11  C8x C    35.1400  -21.0700
            12  C8y C    29.0500  -18.9700
            13  O5a O    30.2400  -21.0700
            14  C1y C    36.3300  -17.5700
            15  C8x C    27.8600  -19.6700
            16  C8x C    29.0500  -17.6400
            17  C1x C    36.3300  -18.9700
            18  N1y N    37.5200  -16.8700
            19  C8x C    26.6700  -19.0400
            20  C8x C    27.8600  -16.9400
            21  C1x C    37.5200  -19.6700
            22  C1x C    38.7800  -17.5700
            23  C8y C    26.6700  -17.6400
            24  C1x C    38.7800  -18.9700
            25  O2a O    25.3400  -16.9400
            26  C1a C    24.1500  -17.6400
            27  C1a C    37.5200  -15.4700
BOND        28
            1     2   3 2
            2     2   4 1
            3     2   5 1
            4     3   6 1
            5     3   7 1
            6     4   8 1
            7     5   9 2
            8     6  10 1
            9     7  11 2
            10    8  12 1
            11    8  13 2
            12   10  14 1
            13   12  15 2
            14   12  16 1
            15   14  17 1
            16   14  18 1
            17   15  19 1
            18   16  20 2
            19   17  21 1
            20   18  22 1
            21   19  23 2
            22   21  24 1
            23   23  25 1
            24   25  26 1
            25    9  11 1
            26   20  23 1
            27   22  24 1
            28   18  27 1

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