| Entry |
|
|---|
| Name |
Perphenazine fendizoate (JAN);
PZC (TN) |
|---|
| Formula |
(C20H14O4)2. C21H26ClN3OS
|
|---|
| Exact mass |
1039.3269
|
|---|
| Mol weight |
1040.6142
|
|---|
| Structure |
|
|---|
| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Therapeutic category: | 1172 |
| Product (DG00875): | D00503<JP/US> D02037<JP> D04038<JP> D04965<JP> |
|
|---|
| Efficacy |
Antipsychotic, Dopamine D2 receptor antagonist |
|---|
| Comment |
Phenothiazine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07029 | Antipsychotics - phenothiazines |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AB Phenothiazines with piperazine structure
N05AB03 Perphenazine
D04038 Perphenazine fendizoate (JAN) <JP>
USP drug classification [BR:br08302]
Antipsychotics
1st Generation/Typical
Perphenazine
D04038 Perphenazine fendizoate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1172 Phenothiazines
D04038 Perphenazine fendizoate (JAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00875 Perphenazine
D04038 Perphenazine fendizoate
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00875 Perphenazine
D04038 Perphenazine fendizoate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00875 Perphenazine
D04038 Perphenazine fendizoate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D04038 Perphenazine fendizoate (JAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D04038
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00875 Perphenazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00875 Perphenazine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00875 Perphenazine
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 75
1 C8x C 35.2403 -18.2384
2 C8x C 35.2403 -19.6359
3 C8x C 36.4506 -20.3347
4 C8x C 37.6609 -19.6359
5 C8y C 37.6609 -18.2384
6 C8y C 36.4506 -17.5396
7 C6a C 36.4506 -16.1423
8 O6a O 35.2236 -15.4336
9 O6a O 37.6441 -15.4531
10 C5a C 38.8899 -17.5286
11 C8y C 40.0929 -18.2231
12 O5a O 38.8896 -16.1422
13 C8x C 40.0933 -19.6355
14 C8x C 41.3038 -20.3340
15 C8y C 42.5140 -19.6348
16 C8y C 42.5135 -18.2223
17 C8x C 41.3030 -17.5239
18 C8y C 43.7121 -17.5299
19 O1a O 43.7200 -20.3307
20 C8x C 44.9140 -18.2236
21 C8x C 46.1243 -17.5247
22 C8x C 46.1241 -16.1272
23 C8x C 44.9221 -15.4334
24 C8x C 43.7119 -16.1324
25 C8x C 23.0046 -16.9716
26 C8x C 23.0046 -18.3755
27 C8x C 24.2204 -19.0774
28 C8y C 25.4362 -18.3755
29 C8y C 25.4362 -16.9716
30 C8x C 24.2204 -16.2697
31 S2x S 26.6520 -19.0774
32 C8y C 27.8678 -18.3755
33 C8y C 27.8678 -16.9716
34 N4y N 26.6520 -16.2697
35 C8x C 29.0836 -19.0774
36 C8x C 30.2994 -18.3755
37 C8y C 30.2994 -16.9716
38 C8x C 29.0836 -16.2697
39 C1b C 26.6520 -14.8658
40 C1b C 27.8699 -14.1627
41 C1b C 29.0697 -14.8556
42 N1y N 30.2598 -14.1685
43 C1x C 31.4546 -14.8586
44 C1x C 32.6704 -14.1567
45 N1y N 32.6706 -12.7529
46 C1x C 31.4758 -12.0629
47 C1x C 30.2600 -12.7646
48 C1b C 33.8988 -12.0438
49 C1b C 35.1101 -12.7431
50 O1a O 36.2946 -12.0593
51 X Cl 31.5193 -16.2674
52 C8x C 35.2403 -18.2384
53 C8x C 35.2403 -19.6359
54 C8x C 36.4506 -20.3347
55 C8x C 37.6609 -19.6359
56 C8y C 37.6609 -18.2384
57 C8y C 36.4506 -17.5396
58 C6a C 36.4506 -16.1423
59 O6a O 35.2236 -15.4336
60 O6a O 37.6441 -15.4531
61 C5a C 38.8899 -17.5286
62 C8y C 40.0929 -18.2231
63 C8x C 40.0933 -19.6355
64 C8x C 41.3038 -20.3340
65 C8y C 42.5140 -19.6348
66 C8y C 42.5135 -18.2223
67 C8x C 41.3030 -17.5239
68 C8y C 43.7121 -17.5299
69 C8x C 44.9140 -18.2236
70 C8x C 46.1243 -17.5247
71 C8x C 46.1241 -16.1272
72 C8x C 44.9221 -15.4334
73 C8x C 43.7119 -16.1324
74 O1a O 43.7200 -20.3307
75 O5a O 38.8896 -16.1422
BOND 82
1 25 26 2
2 26 27 1
3 27 28 2
4 28 29 1
5 29 30 2
6 25 30 1
7 28 31 1
8 31 32 1
9 32 33 1
10 33 34 1
11 29 34 1
12 32 35 2
13 35 36 1
14 36 37 2
15 37 38 1
16 33 38 2
17 34 39 1
18 39 40 1
19 40 41 1
20 41 42 1
21 42 43 1
22 43 44 1
23 44 45 1
24 45 46 1
25 46 47 1
26 42 47 1
27 45 48 1
28 48 49 1
29 49 50 1
30 37 51 1
31 1 2 2
32 2 3 1
33 3 4 2
34 4 5 1
35 5 6 2
36 1 6 1
37 6 7 1
38 7 8 1
39 7 9 2
40 5 10 1
41 10 11 1
42 10 12 2
43 11 13 2
44 13 14 1
45 14 15 2
46 15 16 1
47 16 17 2
48 11 17 1
49 16 18 1
50 15 19 1
51 18 20 2
52 20 21 1
53 21 22 2
54 22 23 1
55 23 24 2
56 18 24 1
57 52 53 2
58 53 54 1
59 54 55 2
60 55 56 1
61 56 57 2
62 52 57 1
63 57 58 1
64 58 59 1
65 58 60 2
66 56 61 1
67 61 62 1
68 61 75 2
69 62 63 2
70 63 64 1
71 64 65 2
72 65 66 1
73 66 67 2
74 62 67 1
75 66 68 1
76 65 74 1
77 68 69 2
78 69 70 1
79 70 71 2
80 71 72 1
81 72 73 2
82 68 73 1
BRACKET 1 33.8800 -21.0700 33.8800 -14.2100
1 46.4100 -14.2100 46.4100 -21.0700
1 2
ORIGINAL 1 1 2 3 4 5 6 7 8 9 10 11 13 14 15 16 17
1 18 20 21 22 23 24 19 12
REPEAT 1 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67
1 68 69 70 71 72 73 74 75
|
|---|
