KEGG   DRUG: Hydralazine polistirex
Entry
D04458                      Drug                                   
Name
Hydralazine polistirex (USAN)
Class
Cardiovascular agent
 DG03231  Antihypertensive
 DG02046  Hydrazinophthalazine derivative
Metabolizing enzyme substrate
 DG02928  NAT substrate
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
ATC code: C02DB02
Chemical structure group: DG00261
Product (DG00261): D01302<JP/US>
Efficacy
Antihypertensive
Comment
Hydrazinophthalazine derivative
Target
AOC3 [HSA:8639] [KO:K00276]
Metabolism
Enzyme: NAT [HSA:9 10]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02D ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON
    C02DB Hydrazinophthalazine derivatives
     C02DB02 Hydralazine
      D04458  Hydralazine polistirex (USAN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG00261  Hydralazine
    D04458  Hydralazine polistirex
  DG02046  Hydrazinophthalazine derivative
   DG00261  Hydralazine
    D04458  Hydralazine polistirex
 Metabolizing enzyme substrate
  DG02928  NAT substrate
   DG00261  Hydralazine
    D04458  Hydralazine polistirex
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00261  Hydralazine
    D04458  Hydralazine polistirex
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Amine oxidases
    AOC3
     D04458  Hydralazine polistirex (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04458
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG00261  Hydralazine
  DG02046  Hydrazinophthalazine derivative
   DG00261  Hydralazine
 Metabolizing enzyme substrate
  DG02928  NAT substrate
   DG00261  Hydralazine
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00261  Hydralazine
Other DBs
PubChem: 47206322
LinkDB

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