| Entry |
|
|---|
| Name |
Perphenazine hydrochloride;
Perphenazine dihydrochloride;
PZC intramuscular injection (TN) |
|---|
| Formula |
C21H26ClN3OS. 2HCl
|
|---|
| Exact mass |
475.1019
|
|---|
| Mol weight |
476.8905
|
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| Structure |
|
|---|
| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Therapeutic category: | 1172 |
| Product (DG00875): | D00503<JP/US> D02037<JP> D04038<JP> D04965<JP> |
|
|---|
| Efficacy |
Antipsychotic, Dopamine D2 receptor antagonist |
|---|
| Comment |
Phenothiazine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07029 | Antipsychotics - phenothiazines |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AB Phenothiazines with piperazine structure
N05AB03 Perphenazine
D04965 Perphenazine hydrochloride <JP>
USP drug classification [BR:br08302]
Antipsychotics
1st Generation/Typical
Perphenazine
D04965 Perphenazine hydrochloride
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1172 Phenothiazines
D04965 Perphenazine hydrochloride
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00875 Perphenazine
D04965 Perphenazine hydrochloride
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00875 Perphenazine
D04965 Perphenazine hydrochloride
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00875 Perphenazine
D04965 Perphenazine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D04965 Perphenazine hydrochloride <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D04965
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00875 Perphenazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00875 Perphenazine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00875 Perphenazine
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 29
1 C8x C 14.1146 -15.4316
2 C8x C 14.1146 -16.8355
3 C8x C 15.3304 -17.5374
4 C8y C 16.5462 -16.8355
5 C8y C 16.5462 -15.4316
6 C8x C 15.3304 -14.7297
7 S2x S 17.7620 -17.5374
8 C8y C 18.9778 -16.8355
9 C8y C 18.9778 -15.4316
10 N4y N 17.7620 -14.7297
11 C8x C 20.1936 -17.5374
12 C8x C 21.4094 -16.8355
13 C8y C 21.4094 -15.4316
14 C8x C 20.1936 -14.7297
15 C1b C 17.7620 -13.3258
16 C1b C 18.9799 -12.6227
17 C1b C 20.1797 -13.3156
18 N1y N 21.3698 -12.6285
19 C1x C 22.5646 -13.3186
20 C1x C 23.7804 -12.6167
21 N1y N 23.7806 -11.2129
22 C1x C 22.5858 -10.5229
23 C1x C 21.3700 -11.2246
24 C1b C 25.0088 -10.5038
25 C1b C 26.2201 -11.2031
26 O1a O 27.4046 -10.5193
27 X Cl 22.6293 -14.7274
28 X Cl 26.8100 -14.8400
29 X Cl 26.8100 -14.8400
BOND 30
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 8 11 2
13 11 12 1
14 12 13 2
15 13 14 1
16 9 14 2
17 10 15 1
18 15 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 22 23 1
26 18 23 1
27 21 24 1
28 24 25 1
29 25 26 1
30 13 27 1
BRACKET 1 25.3400 -16.0300 25.3400 -13.7200
1 27.7900 -13.7200 27.7900 -16.0300
1 2
ORIGINAL 1 28
REPEAT 1 29
|
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