| Entry |
|
|---|
| Name |
Omeprazole sodium injection (JAN);
Omeprazole sodium hydrate;
Omepral (TN) |
|---|
| Formula |
C17H18N3O3S. Na. H2O
|
|---|
| Exact mass |
385.1072
|
|---|
| Mol weight |
385.4132
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 2329 |
| Product (DG00020): | D00455<JP/US> D05261<JP> D05259<US> |
|
|---|
| Efficacy |
Antisecretory (gastric acid), Anti-ulcerative, Proton pump inhibitor |
|---|
| Comment |
Benzimidazole derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2C19 [HSA: 1557]; CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A02 DRUGS FOR ACID RELATED DISORDERS
A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
A02BC Proton pump inhibitors
A02BC01 Omeprazole
D05261 Omeprazole sodium injection (JAN) <JP>
USP drug classification [BR:br08302]
Gastrointestinal Agents
Proton Pump Inhibitors
Omeprazole
D05261 Omeprazole sodium injection (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
23 Digestive organ agents
232 Peptic ulcer agents
2329 Others
D05261 Omeprazole sodium injection (JAN)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG00020 Omeprazole
D05261 Omeprazole sodium injection
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG00020 Omeprazole
D05261 Omeprazole sodium injection
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00020 Omeprazole
D05261 Omeprazole sodium injection
Drug classes [BR:br08332]
Gastrointestinal agent
DG01646 Proton pump inhibitor (PPI)
D05261 Omeprazole sodium injection
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
ATPase
ATP4
D05261 Omeprazole sodium injection (JAN) <JP>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D05261
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D05261
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG00020 Omeprazole
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG00020 Omeprazole
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00020 Omeprazole
|
|---|
| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 26
1 O0 O 35.3501 -17.9200
2 C8x C 22.6100 -20.1600
3 C8y C 22.6100 -21.5600
4 C8x C 23.8700 -22.2600
5 C8y C 25.0600 -21.5600
6 C8y C 25.0600 -20.1600
7 C8x C 23.8700 -19.4600
8 N5x N 26.3900 -21.9800
9 C8y C 27.2300 -20.8600
10 N4x N 26.3900 -19.7400 #-
11 S4a S 28.6300 -20.8600
12 O2a O 21.3500 -22.2600
13 C1a C 20.1600 -21.5600
14 C1b C 29.3300 -22.0500
15 O3c O 29.3300 -19.6700
16 C8y C 30.7300 -22.0500
17 C8y C 31.4300 -23.2400
18 C8y C 32.9000 -23.2400
19 C8y C 33.6000 -22.0500
20 C8x C 32.9000 -20.8600
21 N5x N 31.4300 -20.8600
22 C1a C 35.0000 -22.0500
23 O2a O 33.6000 -24.5000
24 C1a C 35.0000 -24.5000
25 C1a C 30.7300 -24.4300
26 Z Na 27.5800 -17.7800 #+
BOND 26
1 2 3 2
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 2
6 2 7 1
7 5 8 1
8 8 9 2
9 9 10 1
10 6 10 1
11 9 11 1
12 3 12 1
13 12 13 1
14 11 14 1
15 11 15 2
16 14 16 1
17 16 17 2
18 17 18 1
19 18 19 2
20 19 20 1
21 20 21 2
22 16 21 1
23 19 22 1
24 18 23 1
25 23 24 1
26 17 25 1
|
|---|
