| Entry |
|
|---|
| Name |
Josamycin propionate (JP18);
Josamy (TN) |
|---|
| Formula |
C45H73NO16
|
|---|
| Exact mass |
883.4929
|
|---|
| Mol weight |
884.0582
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antibacterial
DG01551 Macrolide antibiotic
DG01876 16-Membered ring macrolide antibiotic
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
|
|---|
| Remark |
| Therapeutic category: | 6145 |
|
|---|
| Efficacy |
Antibacterial, Protein biosynthesis inhibitor |
|---|
| Comment |
Active form of prodrug: Josamycin [DR: D01235]
|
|---|
| Target |
50S ribosomal subunit |
|---|
| Pathway |
|
|---|
| Interaction |
CYP inhibition: CYP3A4 [HSA: 1576]
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
J01FA Macrolides
J01FA07 Josamycin
D05351 Josamycin propionate (JP18)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
61 Antibiotics
614 Acting mainly on gram-positive bacteria and mycoplasma
6145 Josamycins
D05351 Josamycin propionate (JP18)
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01876 16-Membered ring macrolide antibiotic
DG00604 Josamycin
D05351 Josamycin propionate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00604 Josamycin
D05351 Josamycin propionate
Drug classes [BR:br08332]
Antibacterial
DG01551 Macrolide antibiotic
D05351 Josamycin propionate
Antimicrobials [BR:br08307]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
D05351 Josamycin propionate (JP18)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D05351 Josamycin propionate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D05351
Prodrugs [br08324.html]
D05351
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01876 16-Membered ring macrolide antibiotic
DG00604 Josamycin
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00604 Josamycin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
DG00604 Josamycin
Prodrugs [br08324.html]
DG00604
|
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| Other DBs |
|
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| LinkDB |
|
|---|
| KCF data |
ATOM 62
1 C1y C 35.3540 -22.9759
2 C1y C 36.4710 -23.6042
3 O2a O 34.2369 -23.6042
4 C1y C 35.3540 -21.6494
5 C1y C 37.5880 -22.9759
6 N1c N 36.4710 -24.8608
7 C1y C 33.1897 -24.2325
8 O2x O 36.4710 -21.0211
9 C1a C 34.3068 -21.0211
10 C1y C 37.5880 -21.6494
11 O1a O 38.7050 -23.6042
12 C1a C 37.5880 -25.4892
13 C1a C 35.3540 -25.4892
14 C1x C 33.1897 -25.4892
15 O2x O 32.0727 -23.6042
16 O2a O 39.8221 -18.8568
17 C1z C 32.0727 -26.1175
18 C1y C 30.9557 -24.2325
19 C1y C 36.4012 -15.2265
20 C1y C 30.9557 -25.4892
21 C1a C 31.1651 -27.3742
22 O1a O 32.9803 -27.5138
23 C1a C 29.8387 -23.6042
24 C1y C 36.4012 -13.9001
25 C1y C 35.3540 -15.9247
26 O7a O 29.8387 -26.1175
27 C1x C 35.2842 -13.2717
28 C1b C 37.5182 -13.2717
29 C1y C 35.3542 -17.2511
30 O2a O 34.2369 -15.2963
31 C1y C 35.2842 -12.0151
32 C4a C 38.6352 -13.9001
33 C1x C 34.1671 -17.8794
34 C1y C 34.1671 -11.3867
35 C1a C 36.3314 -11.3867
36 O4a O 39.6824 -13.2717
37 C7x C 32.9803 -17.2511
38 C2x C 33.0501 -12.0151
39 O7x O 31.8633 -17.8794
40 O6a O 32.9803 -15.9247
41 C2x C 33.0501 -13.2717
42 C1y C 30.6764 -17.1813
43 C2x C 31.9331 -13.9001
44 C1x C 30.6764 -15.7850
45 C1a C 29.5594 -17.7398
46 C2x C 31.9331 -15.2265
47 C1a C 34.2368 -13.9699
48 C7a C 28.7915 -25.4892
49 C1b C 27.6744 -26.1873
50 O6a O 28.7916 -24.2325
51 C1c C 26.5574 -25.5590
52 C1a C 25.5102 -26.1873
53 C1a C 26.5574 -24.3023
54 O7a O 36.4710 -17.9493
55 C7a C 36.4710 -19.2757
56 O6a O 37.5880 -19.9739
57 C1a C 35.2842 -19.9739
58 O7a O 34.1671 -9.9905
59 C7a C 35.3763 -9.2923
60 C1b C 36.5686 -9.9809
61 O6a O 35.3764 -7.8962
62 C1a C 37.7529 -9.2972
BOND 64
1 10 16 1 #Up
2 14 17 1
3 15 18 1
4 19 16 1 #Down
5 17 20 1
6 17 21 1 #Down
7 17 22 1 #Up
8 18 23 1 #Down
9 19 24 1
10 19 25 1
11 20 26 1 #Up
12 24 27 1
13 24 28 1 #Down
14 25 29 1
15 25 30 1 #Down
16 27 31 1
17 28 32 1
18 29 33 1
19 31 34 1
20 31 35 1 #Down
21 32 36 2
22 33 37 1
23 34 38 1
24 37 39 1
25 37 40 2
26 38 41 2
27 39 42 1
28 41 43 1
29 42 44 1
30 42 45 1 #Down
31 43 46 2
32 8 10 1
33 18 20 1
34 44 46 1
35 30 47 1
36 1 2 1
37 26 48 1
38 1 3 1 #Down
39 48 49 1
40 1 4 1
41 48 50 2
42 2 5 1
43 49 51 1
44 2 6 1 #Up
45 7 3 1 #Up
46 4 8 1
47 4 9 1 #Up
48 5 10 1
49 5 11 1 #Down
50 51 52 1
51 6 12 1
52 51 53 1
53 29 54 1 #Down
54 6 13 1
55 54 55 1
56 7 14 1
57 55 56 2
58 7 15 1
59 55 57 1
60 34 58 1 #Down
61 58 59 1
62 59 60 1
63 59 61 2
64 60 62 1
|
|---|
