| Entry |
|
|---|
| Name |
Piroxicam olamine (USAN) |
|---|
| Formula |
C15H13N3O4S. C2H7NO
|
|---|
| Exact mass |
392.1154
|
|---|
| Mol weight |
392.4295
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01910 Anti-inflammatory drug, oxicams
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
|
|---|
| Remark |
| Product (DG00752): | D00127<JP/US> |
|
|---|
| Efficacy |
Analgesic, Anti-inflammatory, COX inhibitor |
|---|
| Comment |
Oxicams
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AC Oxicams
M01AC01 Piroxicam
D05513 Piroxicam olamine (USAN)
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA07 Piroxicam
D05513 Piroxicam olamine (USAN)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BC Antiinflammatory agents, non-steroids
S01BC06 Piroxicam
D05513 Piroxicam olamine (USAN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01910 Anti-inflammatory drug, oxicams
DG00752 Piroxicam
D05513 Piroxicam olamine
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00752 Piroxicam
D05513 Piroxicam olamine
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D05513 Piroxicam olamine (USAN)
PTGS2 (COX2)
D05513 Piroxicam olamine (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D05513
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01910 Anti-inflammatory drug, oxicams
DG00752 Piroxicam
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00752 Piroxicam
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 27
1 C8y C 5.3304 -7.8075
2 C8y C 5.3304 -9.1845
3 C8y C 6.5196 -7.1065
4 C8x C 4.1350 -7.1254
5 S2x S 6.5321 -9.8730
6 C8x C 4.1350 -9.8792
7 C8y C 7.7213 -7.8013
8 O1a O 6.5134 -5.7484
9 C8x C 2.9584 -7.8075
10 N4y N 7.7338 -9.1907
11 O3c O 4.9799 -10.8431
12 O3c O 7.9215 -10.7930
13 C8x C 2.9584 -9.1845
14 C5a C 8.8977 -7.1129
15 C1a C 8.9103 -9.8666
16 O5a O 8.8916 -5.7547
17 N1b N 10.0816 -7.7883
18 C8y C 11.2587 -7.1005
19 N5x N 12.4362 -7.7725
20 C8x C 13.6131 -7.0847
21 C8x C 13.6060 -5.7217
22 C8x C 12.4221 -5.0461
23 C8x C 11.2453 -5.7339
24 C1b C 17.7570 -9.0302
25 C1b C 16.5415 -8.3288
26 N1a N 18.9667 -8.3288
27 O1a O 15.3318 -9.0302
BOND 28
1 3 8 1
2 4 9 2
3 5 10 1
4 5 11 2
5 5 12 2
6 6 13 2
7 7 14 1
8 10 15 1
9 14 16 2
10 7 10 1
11 9 13 1
12 14 17 1
13 1 2 2
14 17 18 1
15 1 3 1
16 1 4 1
17 2 5 1
18 2 6 1
19 3 7 2
20 18 19 2
21 19 20 1
22 20 21 2
23 21 22 1
24 22 23 2
25 23 18 1
26 24 25 1
27 24 26 1
28 25 27 1
|
|---|
