| Entry |
|
|---|
| Name |
Tripelennamine citrate;
PBZ (TN) |
|---|
| Formula |
C16H21N3. C6H8O7
|
|---|
| Exact mass |
447.2006
|
|---|
| Mol weight |
447.4816
|
|---|
| Structure |
|
|---|
| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
|
|---|
| Remark |
|
|---|
| Efficacy |
Antiallergic, H1 receptor antagonist |
|---|
| Comment |
Phenbenzamine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
|
|---|
| Structure map |
| map07212 | Histamine H1 receptor antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04AA Antihistamines for topical use
D04AA04 Tripelennamine
D06246 Tripelennamine citrate
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AC Substituted ethylene diamines
R06AC04 Tripelennamine
D06246 Tripelennamine citrate
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00383 Tripelennamine
D06246 Tripelennamine citrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00383 Tripelennamine
D06246 Tripelennamine citrate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D06246 Tripelennamine citrate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D06246
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00383 Tripelennamine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00383 Tripelennamine
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 32
1 C8x C 2.8182 -7.5277
2 C8x C 2.8182 -8.9322
3 C8x C 4.0345 -9.6345
4 C8x C 5.2509 -8.9322
5 C8y C 5.2509 -7.5277
6 C8x C 4.0345 -6.8255
7 N5x N 6.4672 -9.6345
8 C8y C 7.6835 -8.9322
9 N1c N 7.6835 -7.5277
10 C1b C 6.4672 -6.8255
11 C8x C 6.4672 -11.0390
12 C8x C 7.6835 -11.7412
13 C8x C 8.8999 -11.0390
14 C8x C 8.8999 -9.6345
15 C1b C 8.8849 -6.8340
16 C1b C 10.0770 -7.5222
17 N1c N 11.2716 -6.8324
18 C1a C 12.4651 -7.5214
19 C1a C 11.2716 -5.4212
20 C1d C 18.7665 -8.6445
21 C1b C 17.5553 -9.3408
22 C1b C 19.9778 -9.3348
23 C6a C 19.4570 -7.4273
24 O1a O 18.0584 -7.4273
25 C6a C 16.3498 -8.6503
26 C6a C 19.9661 -10.7335
27 O6a O 18.7489 -6.2103
28 O6a O 20.8614 -7.4273
29 O6a O 15.1387 -9.3525
30 O6a O 16.4081 -7.2519
31 O6a O 21.1774 -11.4356
32 O6a O 18.7489 -11.4297
BOND 32
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 8 9 1
9 9 10 1
10 5 10 1
11 7 11 2
12 11 12 1
13 12 13 2
14 13 14 1
15 8 14 2
16 9 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 17 19 1
21 20 21 1
22 20 22 1
23 20 23 1
24 20 24 1
25 21 25 1
26 22 26 1
27 23 27 1
28 23 28 2
29 25 29 1
30 25 30 2
31 26 31 1
32 26 32 2
|
|---|
