| Entry |
|
|---|
| Name |
Fesoterodine (INN) |
|---|
| Formula |
C26H37NO3
|
|---|
| Exact mass |
411.2773
|
|---|
| Mol weight |
411.5769
|
|---|
| Structure |
|
|---|
| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00483): | D08923<JP/US> |
|
|---|
| Efficacy |
Overactive bladder agent, Muscarinic acetylcholine receptor antagonist |
|---|
| Comment |
Treatment of overactive bladder
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G04 UROLOGICALS
G04B UROLOGICALS
G04BD Drugs for urinary frequency and incontinence
G04BD11 Fesoterodine
D07226 Fesoterodine (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
DG00483 Fesoterodine
D07226 Fesoterodine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00483 Fesoterodine
D07226 Fesoterodine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00483 Fesoterodine
D07226 Fesoterodine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM2
D07226 Fesoterodine (INN)
CHRM3
D07226 Fesoterodine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07226
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
DG00483 Fesoterodine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00483 Fesoterodine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00483 Fesoterodine
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 30
1 C1c C 11.4800 -24.5000
2 N1c N 12.6700 -25.2000
3 C1b C 13.8600 -24.5700
4 C1b C 15.0500 -25.2700
5 C1c C 16.3800 -24.5700
6 C8y C 17.5700 -25.2700
7 C8x C 18.7600 -24.5700
8 C8y C 20.0200 -25.2700
9 C1b C 21.2100 -24.6400
10 C1a C 11.4800 -23.1700
11 C1c C 12.6700 -26.6700
12 C1a C 11.4100 -27.3000
13 C1a C 13.9300 -27.3000
14 C8y C 17.5700 -26.6700
15 C8x C 20.0200 -26.6700
16 C8x C 18.7600 -27.3700
17 O7a O 16.3800 -27.3000
18 O1a O 22.4000 -25.3400
19 C1a C 10.2900 -25.2000
20 C8y C 16.3800 -23.1700
21 C8x C 17.6400 -22.4700
22 C8x C 17.6400 -21.0700
23 C8x C 16.4500 -20.3700
24 C8x C 15.1900 -21.0000
25 C8x C 15.1900 -22.4000
26 C7a C 16.3877 -28.7000
27 O6a O 17.5982 -29.3900
28 C1c C 15.1734 -29.4101
29 C1a C 13.9655 -28.7214
30 C1a C 15.1812 -30.8000
BOND 31
1 1 2 1
2 2 3 1
3 3 4 1
4 5 4 1
5 5 6 1
6 6 7 1
7 7 8 2
8 8 9 1
9 1 10 1
10 2 11 1
11 11 12 1
12 11 13 1
13 6 14 2
14 8 15 1
15 14 16 1
16 16 15 2
17 14 17 1
18 9 18 1
19 1 19 1
20 5 20 1 #Down
21 20 21 2
22 21 22 1
23 22 23 2
24 23 24 1
25 24 25 2
26 20 25 1
27 17 26 1
28 26 27 2
29 26 28 1
30 28 29 1
31 28 30 1
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