| Entry |
|
|---|
| Name |
Bunazosin (INN) |
|---|
| Formula |
C19H27N5O3
|
|---|
| Exact mass |
373.2114
|
|---|
| Mol weight |
373.4494
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG03231 Antihypertensive
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
|
|---|
| Remark |
| Product (DG01316): | D01887<JP> |
|
|---|
| Efficacy |
Antihypertensive, alpha1-Adrenergic receptor antagonist |
|---|
| Comment |
Prazosin derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07215 | alpha-Adrenergic receptor agonists/antagonists |
|
|---|
| Brite |
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG01316 Bunazosin
D07550 Bunazosin
DG03231 Antihypertensive
DG01316 Bunazosin
D07550 Bunazosin
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01316 Bunazosin
D07550 Bunazosin
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D07550 Bunazosin (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG01316 Bunazosin
DG03231 Antihypertensive
DG01316 Bunazosin
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01316 Bunazosin
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 27
1 C8y C 29.2600 -18.8300
2 C8y C 29.2600 -20.2300
3 C8x C 28.0000 -20.9300
4 C8x C 28.0000 -18.1300
5 C8y C 26.8100 -18.8300
6 C8y C 26.8100 -20.2300
7 C8y C 25.6200 -20.9300
8 N5x N 24.3600 -20.2300
9 C8y C 24.3600 -18.8300
10 N5x N 25.6200 -18.1300
11 N1y N 23.1700 -18.1300
12 C1x C 23.1700 -16.7300
13 C1x C 22.1900 -15.8200
14 C1x C 21.9800 -18.9700
15 N1y N 20.8600 -16.0300
16 C1x C 20.6500 -18.5500
17 C1x C 20.1600 -17.2200
18 C5a C 20.1600 -14.7700
19 C1b C 18.7600 -14.7700
20 C1b C 18.0600 -13.5800
21 C1a C 16.6600 -13.5800
22 O5a O 20.8600 -13.5800
23 O2a O 30.4500 -18.1300
24 C1a C 31.6400 -18.8300
25 O2a O 30.4500 -20.9300
26 C1a C 31.6400 -20.2300
27 N1a N 25.6200 -22.3300
BOND 29
1 12 13 1
2 1 2 2
3 11 14 1
4 2 3 1
5 13 15 1
6 3 6 2
7 14 16 1
8 5 4 2
9 15 17 1
10 16 17 1
11 5 6 1
12 15 18 1
13 6 7 1
14 18 19 1
15 7 8 2
16 19 20 1
17 8 9 1
18 20 21 1
19 9 10 2
20 18 22 2
21 10 5 1
22 1 23 1
23 4 1 1
24 23 24 1
25 9 11 1
26 2 25 1
27 25 26 1
28 11 12 1
29 7 27 1
|
|---|
