| Entry |
|
|---|
| Name |
Cilazapril (INN);
Inhibace (TN) |
|---|
| Formula |
C22H31N3O5
|
|---|
| Exact mass |
417.2264
|
|---|
| Mol weight |
417.4986
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
|
|---|
| Remark |
|
|---|
| Efficacy |
Antihypertensive, Angiotensin-converting enzyme inhibitor |
|---|
| Comment |
Active form of prodrug: Cilazaprilat [CPD: C17309]
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07217 | Renin-angiotensin system inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
C09A ACE INHIBITORS, PLAIN
C09AA ACE inhibitors, plain
C09AA08 Cilazapril
D07699 Cilazapril (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG00340 Cilazapril
D07699 Cilazapril
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
DG00340 Cilazapril
D07699 Cilazapril
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Peptidyl-dipeptidases
ACE (CD143)
D07699 Cilazapril (INN)
Prodrugs [br08324.html]
D07699
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG00340 Cilazapril
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
DG00340 Cilazapril
Prodrugs [br08324.html]
DG00340
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 30
1 C1x C 19.3200 -20.7900
2 N1y N 18.4800 -19.6700
3 N1y N 18.8300 -18.3400
4 C5x C 20.0900 -17.7800
5 C1x C 20.7200 -20.7900
6 C1y C 21.3500 -18.4100
7 C1x C 21.6300 -19.7400
8 C1y C 17.7800 -17.3600
9 C1x C 16.4500 -17.7800
10 C1x C 16.1000 -19.1100
11 C1x C 17.1500 -20.0900
12 C6a C 18.1300 -16.0300
13 O6a O 19.3900 -15.6100
14 O6a O 17.0100 -15.0500
15 O5x O 20.1600 -16.3800
16 C7a C 24.0800 -19.7400
17 C1c C 24.0800 -18.3400
18 N1b N 22.8200 -17.6400
19 C1b C 25.2700 -17.6400
20 C1b C 26.4600 -18.3400
21 C8y C 27.6500 -17.6400
22 O7a O 25.2700 -20.4400
23 O6a O 22.8900 -20.4400
24 C1b C 26.4600 -19.7400
25 C1a C 27.6500 -20.4400
26 C8x C 28.8400 -18.3400
27 C8x C 30.0300 -17.6400
28 C8x C 30.0300 -16.2400
29 C8x C 28.8400 -15.5400
30 C8x C 27.6500 -16.2400
BOND 32
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 1
9 8 9 1
10 9 10 1
11 10 11 1
12 2 11 1
13 8 12 1 #Up
14 12 13 2
15 12 14 1
16 4 15 2
17 17 16 1 #Up
18 17 18 1
19 6 18 1 #Up
20 17 19 1
21 19 20 1
22 20 21 1
23 16 22 1
24 16 23 2
25 22 24 1
26 24 25 1
27 21 26 2
28 26 27 1
29 27 28 2
30 28 29 1
31 29 30 2
32 21 30 1
|
|---|
