| Entry |
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| Name |
Dexamethasone sodium hemisulfate;
Dexamethasone 21-sodium sulfate;
Colircusi Dexametasona (TN) |
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| Formula |
C22H28FO8S. Na
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| Exact mass |
494.1387
|
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| Mol weight |
494.5061
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
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| Remark |
| Product (DG00011): | D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP> |
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
CYP induction: CYP3A4 [HSA: 1576]
|
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC02 Dexamethasone
D07798 Dexamethasone sodium hemisulfate
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA09 Dexamethasone
D07798 Dexamethasone sodium hemisulfate
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AB Corticosteroids, moderately potent (group II)
D07AB19 Dexamethasone
D07798 Dexamethasone sodium hemisulfate
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XB Corticosteroids, moderately potent, other combinations
D07XB05 Dexamethasone
D07798 Dexamethasone sodium hemisulfate
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA03 Dexamethasone
D07798 Dexamethasone sodium hemisulfate
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB02 Dexamethasone
D07798 Dexamethasone sodium hemisulfate
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD03 Dexamethasone
D07798 Dexamethasone sodium hemisulfate
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA01 Dexamethasone
D07798 Dexamethasone sodium hemisulfate
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB01 Dexamethasone
D07798 Dexamethasone sodium hemisulfate
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA06 Dexamethasone
D07798 Dexamethasone sodium hemisulfate
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03B CORTICOSTEROIDS
S03BA Corticosteroids
S03BA01 Dexamethasone
D07798 Dexamethasone sodium hemisulfate
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
D07798 Dexamethasone sodium hemisulfate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
D07798 Dexamethasone sodium hemisulfate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
D07798 Dexamethasone sodium hemisulfate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D07798 Dexamethasone sodium hemisulfate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07798
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 33
1 Z Na 21.3933 -25.5423 #+
2 C2x C 10.0800 -25.7600
3 C5x C 10.0800 -27.0900
4 C2x C 11.2700 -27.7900
5 C2y C 12.4600 -27.0900
6 C1z C 12.4600 -25.7600
7 C2x C 11.2700 -25.1300
8 C1x C 13.5800 -27.7900
9 C1x C 14.7700 -27.0900
10 C1y C 14.7700 -25.7600
11 C1z C 13.5800 -25.1300
12 C1y C 15.9600 -25.1300
13 C1z C 15.9600 -23.7300
14 C1x C 14.7700 -23.1000
15 C1y C 13.5800 -23.7300
16 C1x C 18.3400 -25.1300
17 C1y C 18.3400 -23.7300
18 C1z C 17.1500 -23.1000
19 O1a O 18.1300 -22.1200
20 X F 13.5800 -26.3900
21 O5x O 8.9600 -27.7900
22 C1a C 15.9600 -22.4000
23 C1a C 12.4600 -24.4300
24 O1a O 12.6700 -22.8200
25 C1a C 19.6700 -23.1700
26 C5a C 17.1500 -21.2800
27 O5a O 15.9600 -20.5800
28 C1b C 18.3653 -20.5849
29 O2a O 19.5537 -21.2777
30 S4a S 20.7501 -20.5935
31 O1d O 21.3876 -21.8106
32 O1d O 20.1631 -19.2955
33 O1d O 21.9891 -19.9890 #-
BOND 35
1 2 3 1
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 1
6 2 7 2
7 5 8 1
8 8 9 1
9 9 10 1
10 10 11 1
11 6 11 1
12 10 12 1
13 12 13 1
14 13 14 1
15 14 15 1
16 11 15 1
17 16 17 1
18 17 18 1
19 13 18 1
20 18 19 1 #Down
21 11 20 1 #Down
22 3 21 2
23 12 16 1
24 13 22 1 #Up
25 6 23 1 #Up
26 15 24 1 #Up
27 17 25 1 #Down
28 26 27 2
29 18 26 1 #Up
30 26 28 1
31 28 29 1
32 29 30 1
33 30 31 2
34 30 32 2
35 30 33 1
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