| Entry |
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| Name |
Dexamethasone 21-tebutate;
Dexamethasone tertiary butyl acetate;
Dexamedium [veterinary] (TN) |
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| Formula |
C28H39FO6
|
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| Exact mass |
490.2731
|
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| Mol weight |
490.6041
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
|
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| Remark |
| Product (DG00011): | D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP> |
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
CYP induction: CYP3A4 [HSA: 1576]
|
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC02 Dexamethasone
D07799 Dexamethasone 21-tebutate
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA09 Dexamethasone
D07799 Dexamethasone 21-tebutate
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AB Corticosteroids, moderately potent (group II)
D07AB19 Dexamethasone
D07799 Dexamethasone 21-tebutate
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XB Corticosteroids, moderately potent, other combinations
D07XB05 Dexamethasone
D07799 Dexamethasone 21-tebutate
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA03 Dexamethasone
D07799 Dexamethasone 21-tebutate
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB02 Dexamethasone
D07799 Dexamethasone 21-tebutate
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD03 Dexamethasone
D07799 Dexamethasone 21-tebutate
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA01 Dexamethasone
D07799 Dexamethasone 21-tebutate
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB01 Dexamethasone
D07799 Dexamethasone 21-tebutate
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA06 Dexamethasone
D07799 Dexamethasone 21-tebutate
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03B CORTICOSTEROIDS
S03BA Corticosteroids
S03BA01 Dexamethasone
D07799 Dexamethasone 21-tebutate
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
D07799 Dexamethasone 21-tebutate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
D07799 Dexamethasone 21-tebutate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
D07799 Dexamethasone 21-tebutate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D07799 Dexamethasone 21-tebutate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07799
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 35
1 C2x C 10.9200 -21.4200
2 C5x C 10.9200 -22.7500
3 C2x C 12.1100 -23.4500
4 C2y C 13.3000 -22.7500
5 C1z C 13.3000 -21.4200
6 C2x C 12.1100 -20.7900
7 C1x C 14.4200 -23.4500
8 C1x C 15.6100 -22.7500
9 C1y C 15.6100 -21.4200
10 C1z C 14.4200 -20.7900
11 C1y C 16.8000 -20.7900
12 C1z C 16.8000 -19.3900
13 C1x C 15.6100 -18.7600
14 C1y C 14.4200 -19.3900
15 C1x C 19.1800 -20.7900
16 C1y C 19.1800 -19.3900
17 C1z C 17.9900 -18.7600
18 O1a O 18.9700 -17.7800
19 X F 14.4200 -22.0500
20 O5x O 9.8000 -23.4500
21 C1a C 16.8000 -18.0600
22 C1a C 13.3000 -20.0900
23 O1a O 13.5100 -18.4800
24 C1a C 20.5800 -18.8300
25 C5a C 17.9900 -16.9400
26 O5a O 16.8000 -16.2400
27 C1b C 19.2053 -16.2449
28 O7a O 20.3937 -16.9377
29 C7a C 21.5901 -16.2535
30 C1b C 22.7713 -16.9419
31 O6a O 21.5855 -14.8402
32 C1d C 23.9713 -16.2555
33 C1a C 24.6652 -17.4375
34 C1a C 25.1215 -15.4889
35 C1a C 23.2199 -15.0394
BOND 38
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 15 16 1
18 16 17 1
19 12 17 1
20 17 18 1 #Down
21 10 19 1 #Down
22 2 20 2
23 11 15 1
24 12 21 1 #Up
25 5 22 1 #Up
26 14 23 1 #Up
27 16 24 1 #Down
28 25 26 2
29 17 25 1 #Up
30 25 27 1
31 27 28 1
32 28 29 1
33 29 30 1
34 29 31 2
35 30 32 1
36 32 33 1
37 32 34 1
38 32 35 1
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