| Entry |
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| Name |
Dexamethasone phosphate;
Decadron-phosphate (TN) |
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| Formula |
C22H30FO8P
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| Exact mass |
472.1662
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| Mol weight |
472.441
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
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| Remark |
| Product (DG00011): | D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP> |
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
CYP induction: CYP3A4 [HSA: 1576]
|
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC02 Dexamethasone
D07802 Dexamethasone phosphate
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA09 Dexamethasone
D07802 Dexamethasone phosphate
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AB Corticosteroids, moderately potent (group II)
D07AB19 Dexamethasone
D07802 Dexamethasone phosphate
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XB Corticosteroids, moderately potent, other combinations
D07XB05 Dexamethasone
D07802 Dexamethasone phosphate
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA03 Dexamethasone
D07802 Dexamethasone phosphate
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB02 Dexamethasone
D07802 Dexamethasone phosphate
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD03 Dexamethasone
D07802 Dexamethasone phosphate
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA01 Dexamethasone
D07802 Dexamethasone phosphate
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB01 Dexamethasone
D07802 Dexamethasone phosphate
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA06 Dexamethasone
D07802 Dexamethasone phosphate
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03B CORTICOSTEROIDS
S03BA Corticosteroids
S03BA01 Dexamethasone
D07802 Dexamethasone phosphate
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
D07802 Dexamethasone phosphate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
D07802 Dexamethasone phosphate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
D07802 Dexamethasone phosphate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D07802 Dexamethasone phosphate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07802
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 32
1 C1y C 23.5200 -19.2500
2 C1y C 22.3300 -19.9500
3 C1z C 23.5200 -17.8500
4 C1x C 25.9000 -19.2500
5 C1z C 21.1400 -19.2500
6 C1x C 22.3300 -21.2800
7 C1z C 24.7100 -17.2200
8 C1x C 22.3300 -17.2200
9 C1a C 23.5200 -16.5200
10 C1y C 25.9000 -17.9200
11 C1z C 19.9500 -19.9500
12 C1y C 21.1400 -17.8500
13 X F 21.1400 -20.5800
14 C1x C 21.1400 -21.9800
15 C5a C 24.7100 -15.8200
16 O1a O 26.0400 -16.8000
17 C1a C 27.2300 -17.7100
18 C2y C 19.9500 -21.2800
19 C2x C 18.7600 -19.2500
20 C1a C 19.9500 -18.5500
21 O1a O 19.9500 -17.1500
22 C1b C 25.9000 -15.1200
23 O5a O 23.5200 -15.1200
24 C2x C 18.7600 -21.9800
25 C2x C 17.5700 -19.9500
26 O2b O 27.0900 -15.8200
27 C5x C 17.5700 -21.2800
28 P1b P 28.2100 -15.0500
29 O5x O 16.3800 -21.9800
30 O1c O 29.4000 -14.2800
31 O1c O 27.4400 -13.8600
32 O1c O 28.9100 -16.2624
BOND 35
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 1
8 3 9 1 #Up
9 4 10 1
10 5 11 1
11 5 12 1
12 5 13 1 #Down
13 6 14 1
14 7 15 1 #Up
15 7 16 1 #Down
16 10 17 1 #Down
17 11 18 1
18 11 19 1
19 11 20 1 #Up
20 12 21 1 #Up
21 15 22 1
22 15 23 2
23 18 24 2
24 19 25 2
25 22 26 1
26 24 27 1
27 26 28 1
28 27 29 2
29 28 30 1
30 28 31 1
31 7 10 1
32 8 12 1
33 14 18 1
34 25 27 1
35 28 32 2
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