| Entry |
|
|---|
| Name |
Dexchlorpheniramine (INN);
d-Chloropheniramine;
Dapriton (TN) |
|---|
| Formula |
C16H19ClN2
|
|---|
| Exact mass |
274.1237
|
|---|
| Mol weight |
274.7885
|
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| Structure |
|
|---|
| Simcomp |
|
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| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
|
|---|
| Remark |
| Product (DG01098): | D00668<JP/US> |
|
|---|
| Efficacy |
Antiallergic, H1 receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
|
|---|
| Metabolism |
|
|---|
| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
|
|---|
| Structure map |
| map07212 | Histamine H1 receptor antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AB Substituted alkylamines
R06AB02 Dexchlorpheniramine
D07803 Dexchlorpheniramine (INN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01098 Dexchlorpheniramine
D07803 Dexchlorpheniramine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01098 Dexchlorpheniramine
D07803 Dexchlorpheniramine
DG01633 CYP3A/CYP3A4 substrate
DG01098 Dexchlorpheniramine
D07803 Dexchlorpheniramine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG01098 Dexchlorpheniramine
D07803 Dexchlorpheniramine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D07803 Dexchlorpheniramine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07803
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01098 Dexchlorpheniramine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01098 Dexchlorpheniramine
DG01633 CYP3A/CYP3A4 substrate
DG01098 Dexchlorpheniramine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG01098 Dexchlorpheniramine
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 19
1 C8x C 15.4000 -34.3000
2 C8y C 15.4000 -35.7000
3 C8x C 16.6124 -36.4000
4 C8x C 17.8249 -35.7000
5 C8y C 17.8249 -34.3000
6 C8x C 16.6124 -33.6000
7 C1c C 19.0560 -33.5890
8 C8y C 20.2612 -34.2847
9 C8x C 20.2616 -35.6996
10 C8x C 21.4742 -36.3993
11 C8x C 22.6865 -35.6989
12 C8x C 22.6860 -34.2839
13 N5x N 21.4734 -33.5843
14 X Cl 14.1876 -36.4000
15 C1b C 19.0557 -32.2001
16 C1b C 20.2562 -31.5066
17 N1c N 20.2561 -30.1002
18 C1a C 19.0241 -29.3888
19 C1a C 21.4489 -29.4113
BOND 20
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 8 9 2
10 9 10 1
11 10 11 2
12 11 12 1
13 12 13 2
14 8 13 1
15 2 14 1
16 7 15 1 #Down
17 15 16 1
18 16 17 1
19 17 18 1
20 17 19 1
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