| Entry |
|
|---|
| Name |
Fosinopril (INN);
Monopril (TN) |
|---|
| Formula |
C30H46NO7P
|
|---|
| Exact mass |
563.3012
|
|---|
| Mol weight |
563.66
|
|---|
| Structure |
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|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
|
|---|
| Remark |
| Product (DG00341): | D00622<US> |
| Product (mixture): | D10280<US> |
|
|---|
| Efficacy |
Antihypertensive, Angiotensin-converting enzyme inhibitor |
|---|
| Comment |
Active form of prodrug: Fosinoprilat [DR: D03772]
|
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| Target |
|
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| Pathway |
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|---|
| Interaction |
|
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| Structure map |
| map07217 | Renin-angiotensin system inhibitors |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
C09A ACE INHIBITORS, PLAIN
C09AA ACE inhibitors, plain
C09AA09 Fosinopril
D07992 Fosinopril (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG00341 Fosinopril
D07992 Fosinopril
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
DG00341 Fosinopril
D07992 Fosinopril
Target-based classification of drugs [BR:br08310]
Peptidases and inhibitors
Metallo peptidases
Family M2
ACE (CD143)
D07992 Fosinopril (INN)
Prodrugs [br08324.html]
D07992
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG00341 Fosinopril
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
DG00341 Fosinopril
Prodrugs [br08324.html]
DG00341
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 39
1 C8x C 18.0016 -17.3724
2 C8x C 18.0016 -18.7734
3 C8x C 19.1925 -19.4740
4 C8x C 20.3833 -18.7734
5 C8y C 20.3833 -17.3724
6 C8x C 19.1925 -16.6719
7 C1b C 21.5742 -16.6719
8 C1b C 22.8351 -17.3724
9 C1b C 24.0260 -16.6719
10 C1b C 25.2169 -17.3724
11 P1a P 26.4778 -16.6719
12 C1b C 27.6687 -17.3724
13 C5a C 28.8595 -16.6719
14 N1y N 30.1205 -17.3724
15 O3b O 26.4778 -15.2008
16 O5a O 28.8595 -15.2709
17 C1x C 30.5408 -18.7034
18 C1y C 31.9418 -18.7034
19 C1x C 32.3621 -17.3724
20 C1y C 31.2413 -16.5318
21 C1y C 32.6423 -19.9643
22 C1x C 31.9418 -21.1552
23 C1x C 32.6423 -22.3461
24 C1x C 34.0433 -22.3461
25 C1x C 34.7439 -21.1552
26 C1x C 34.0433 -19.9643
27 C6a C 31.2413 -15.1308
28 O6a O 32.4322 -14.4303
29 O6a O 30.0504 -14.4303
30 O2b O 26.4778 -18.2130
31 C1c C 26.4778 -19.6141
32 O7a O 25.2869 -20.3146
33 C1c C 27.6687 -20.3146
34 C1a C 28.8595 -19.6141
35 C1a C 27.6687 -21.7156
36 C7a C 24.0961 -19.6141
37 C1b C 22.9052 -20.3146
38 O6a O 24.0961 -18.2130
39 C1a C 21.7143 -19.6141
BOND 41
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 10 11 1
12 11 12 1
13 12 13 1
14 13 14 1
15 11 15 2
16 13 16 2
17 14 17 1
18 17 18 1
19 18 19 1
20 19 20 1
21 14 20 1
22 21 22 1
23 22 23 1
24 23 24 1
25 24 25 1
26 25 26 1
27 21 26 1
28 18 21 1 #Up
29 20 27 1 #Down
30 27 28 1
31 27 29 2
32 11 30 1
33 30 31 1
34 31 32 1 #Up
35 31 33 1
36 33 34 1
37 33 35 1
38 32 36 1
39 36 37 1
40 36 38 2
41 37 39 1
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