| Entry |
|
|---|
| Name |
Hydrocodone hydrochloride;
Dihydrocodeinone hydrochloride;
Dicodid (TN) |
|---|
| Formula |
C18H21NO3. HCl
|
|---|
| Exact mass |
335.1288
|
|---|
| Mol weight |
335.8252
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
Metabolizing enzyme substrate
DG02919 CYP2B6 substrate
DG01639 CYP2C19 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG01075): | D03725<US> |
| Product (mixture): | D11075<US> D11076<US> D11087<US> |
|
|---|
| Efficacy |
Antitussive, Opioid receptor agonist |
|---|
| Comment |
Opium alkaloid
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]; CYP2D6 [HSA: 1565], CYP2B6 [HSA: 1555], CYP2C19 [HSA: 1557]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R05 COUGH AND COLD PREPARATIONS
R05D COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
R05DA Opium alkaloids and derivatives
R05DA03 Hydrocodone
D08046 Hydrocodone hydrochloride
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG01075 Hydrocodone
D08046 Hydrocodone hydrochloride
Metabolizing enzyme substrate
DG02919 CYP2B6 substrate
DG01075 Hydrocodone
D08046 Hydrocodone hydrochloride
DG01639 CYP2C19 substrate
DG01075 Hydrocodone
D08046 Hydrocodone hydrochloride
DG01644 CYP2D6 substrate
DG01075 Hydrocodone
D08046 Hydrocodone hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01075 Hydrocodone
D08046 Hydrocodone hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D08046 Hydrocodone hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08046
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG01075 Hydrocodone
Metabolizing enzyme substrate
DG02919 CYP2B6 substrate
DG01075 Hydrocodone
DG01639 CYP2C19 substrate
DG01075 Hydrocodone
DG01644 CYP2D6 substrate
DG01075 Hydrocodone
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01075 Hydrocodone
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 23
1 C1z C 23.3800 -18.5500
2 C8y C 23.3800 -17.2200
3 C1y C 24.5700 -19.2500
4 C1y C 22.2600 -19.1800
5 C1x C 24.5700 -17.9200
6 C8y C 22.2600 -16.5900
7 C8y C 24.5700 -16.5900
8 C1y C 25.6900 -18.5500
9 C1x C 24.5700 -20.5100
10 O2x O 21.0000 -17.8500
11 C5x C 22.2600 -20.5100
12 C1x C 26.8800 -17.9200
13 C8y C 22.2600 -15.2600
14 C1x C 25.6900 -17.2900
15 C8x C 24.5700 -15.2600
16 N1y N 26.8800 -19.2500
17 C1x C 23.3800 -21.2100
18 O5x O 21.2100 -21.2100
19 C8x C 23.4500 -14.6300
20 O2a O 21.2100 -14.6300
21 C1a C 20.0200 -15.2600
22 C1a C 28.2800 -19.2500
23 X Cl 31.4300 -17.4300
BOND 26
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1 #Up
5 2 6 2
6 2 7 1
7 3 8 1
8 3 9 1
9 4 10 1 #Down
10 4 11 1
11 5 12 1
12 6 13 1
13 7 14 1
14 7 15 2
15 8 16 1 #Up
16 9 17 1
17 11 18 2
18 13 19 2
19 13 20 1
20 20 21 1
21 6 10 1
22 8 14 1
23 11 17 1
24 12 16 1
25 15 19 1
26 16 22 1
|
|---|
