| Entry |
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| Name |
Imipramine pamoate (USP);
Imipramine embonate;
Tofranil-pm (TN) |
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| Product |
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| Generic |
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| Formula |
(C19H24N2)2. C23H16O6
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| Exact mass |
948.4826
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| Mol weight |
949.1841
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| Structure |
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| Class |
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG01728 Tricyclic antidepressant
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01639 CYP2C19 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Product (DG00928): | D00815<JP/US> D08071<US> |
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| Efficacy |
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI) |
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| Disease |
|
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| Comment |
Active form of prodrug: Desipramine [DR: D07791]
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]; CYP1A2 [HSA: 1544], CYP3A4 [HSA: 1576], CYP2C19 [HSA: 1557]
|
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| Interaction |
|
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| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AA Non-selective monoamine reuptake inhibitors
N06AA02 Imipramine
D08071 Imipramine pamoate (USP) <US>
USP drug classification [BR:br08302]
Antidepressants
Tricyclics
Imipramine
D08071 Imipramine pamoate (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00928 Imipramine
D08071 Imipramine pamoate
DG01728 Tricyclic antidepressant
DG00928 Imipramine
D08071 Imipramine pamoate
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00928 Imipramine
D08071 Imipramine pamoate
DG01639 CYP2C19 substrate
DG00928 Imipramine
D08071 Imipramine pamoate
DG01644 CYP2D6 substrate
DG00928 Imipramine
D08071 Imipramine pamoate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00928 Imipramine
D08071 Imipramine pamoate
Drug classes [BR:br08332]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
D08071 Imipramine pamoate
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D08071 Imipramine pamoate (USP) <US>
SLC6A4 (HTT)
D08071 Imipramine pamoate (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08071
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00928 Imipramine
DG01728 Tricyclic antidepressant
DG00928 Imipramine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00928 Imipramine
DG01639 CYP2C19 substrate
DG00928 Imipramine
DG01644 CYP2D6 substrate
DG00928 Imipramine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00928 Imipramine
Prodrugs [br08324.html]
DG00928
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 71
1 C1x C 19.6700 -22.5400
2 C8y C 18.8300 -21.4200
3 C8y C 19.1800 -20.0200
4 N1y N 20.4400 -19.4600
5 C1x C 21.0700 -22.5400
6 C8y C 21.7000 -20.0900
7 C8y C 21.9800 -21.4900
8 C8x C 18.1300 -19.0400
9 C8x C 16.8000 -19.4600
10 C8x C 16.4500 -20.7900
11 C8x C 17.5000 -21.8400
12 C8x C 23.3100 -21.9100
13 C8x C 24.3600 -21.0000
14 C8x C 24.0800 -19.5300
15 C8x C 22.7500 -19.1100
16 C1b C 20.4400 -18.0600
17 C1b C 21.6300 -17.3600
18 C1b C 22.8200 -18.0600
19 N1c N 24.0800 -17.4300
20 C1a C 25.2700 -18.1300
21 C1a C 24.0800 -16.0300
22 C8x C 29.6800 -20.6500
23 C8x C 29.6800 -21.9800
24 C8x C 30.8700 -22.6800
25 C8x C 32.0600 -21.9800
26 C8y C 32.0600 -20.6500
27 C8y C 30.8700 -19.9500
28 C8y C 33.2500 -19.9500
29 C8y C 33.2500 -18.5500
30 C8y C 32.0600 -17.9200
31 C8x C 30.8700 -18.5500
32 C1b C 35.0700 -20.7900
33 C8y C 36.6800 -19.9500
34 C8y C 37.8700 -20.6500
35 C8y C 39.0600 -19.9500
36 C8x C 39.0600 -18.5500
37 C8y C 37.8700 -17.9200
38 C8y C 36.6800 -18.6200
39 C8x C 37.8700 -21.9800
40 C8x C 39.0600 -22.6800
41 C8x C 40.2500 -21.9800
42 C8x C 40.2500 -20.6500
43 C6a C 32.0600 -16.5200
44 O6a O 33.2500 -15.8200
45 O6a O 30.8700 -15.8200
46 C6a C 37.8700 -16.5200
47 O6a O 36.6800 -15.8200
48 O6a O 39.0600 -15.8200
49 O1a O 34.4400 -17.9200
50 O1a O 35.4900 -17.9200
51 C1x C 19.6700 -22.5400
52 C1x C 21.0700 -22.5400
53 C8y C 21.9800 -21.4900
54 C8y C 21.7000 -20.0900
55 N1y N 20.4400 -19.4600
56 C8y C 19.1800 -20.0200
57 C8y C 18.8300 -21.4200
58 C8x C 17.5000 -21.8400
59 C8x C 16.4500 -20.7900
60 C8x C 16.8000 -19.4600
61 C8x C 18.1300 -19.0400
62 C1b C 20.4400 -18.0600
63 C1b C 21.6300 -17.3600
64 C1b C 22.8200 -18.0600
65 N1c N 24.0800 -17.4300
66 C1a C 25.2700 -18.1300
67 C1a C 24.0800 -16.0300
68 C8x C 22.7500 -19.1100
69 C8x C 24.0800 -19.5300
70 C8x C 24.3600 -21.0000
71 C8x C 23.3100 -21.9100
BOND 78
1 22 23 2
2 23 24 1
3 24 25 2
4 25 26 1
5 26 27 2
6 22 27 1
7 26 28 1
8 28 29 2
9 29 30 1
10 30 31 2
11 27 31 1
12 28 32 1
13 32 33 1
14 33 34 1
15 34 35 2
16 35 36 1
17 36 37 2
18 37 38 1
19 33 38 2
20 34 39 1
21 39 40 2
22 40 41 1
23 41 42 2
24 35 42 1
25 30 43 1
26 43 44 2
27 43 45 1
28 37 46 1
29 46 47 2
30 46 48 1
31 29 49 1
32 38 50 1
33 3 4 1
34 1 5 1
35 4 6 1
36 2 3 1
37 5 7 1
38 1 2 1
39 6 7 1
40 3 8 2
41 8 9 1
42 9 10 2
43 10 11 1
44 2 11 2
45 7 12 2
46 12 13 1
47 13 14 2
48 14 15 1
49 6 15 2
50 4 16 1
51 16 17 1
52 17 18 1
53 18 19 1
54 19 20 1
55 19 21 1
56 56 55 1
57 51 52 1
58 55 54 1
59 57 56 1
60 52 53 1
61 51 57 1
62 54 53 1
63 56 61 2
64 61 60 1
65 60 59 2
66 59 58 1
67 57 58 2
68 53 71 2
69 71 70 1
70 70 69 2
71 69 68 1
72 54 68 2
73 55 62 1
74 62 63 1
75 63 64 1
76 64 65 1
77 65 66 1
78 65 67 1
BRACKET 1 15.0500 -23.1000 15.0500 -15.2600
1 26.9500 -15.2600 26.9500 -23.1000
1 2
ORIGINAL 1 1 5 7 6 4 3 2 11 10 9 8 16 17 18 19 20
1 21 15 14 13 12
REPEAT 1 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66
1 67 68 69 70 71
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