KEGG   DRUG: Lidocaine hydrochloride monohydrate
Entry
D08127                      Drug                                   
Name
Lidocaine hydrochloride monohydrate;
Lidocaine (TN);
Zingo (TN)
Product
  Generic
1% LIDOCAINE HCI (HF Acquisition Co LLC), 1% LIDOCAINE HCI (HF Acquisition Co LLC), 2% LIDOCAINE HCI (HF Acquisition Co LLC), 2% LIDOCAINE HCI (HF Acquisition Co. LLC), LIDOCAINE HCI (HF Acquisition Co LLC), LIDOCAINE HCI (HF Acquisition Co. LLC), LIDOCAINE HCL (HF Acquisition Co LLC), LIDOCAINE HCL (HF Acquisition Co LLC), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions), LIDOCAINE HYDROCHLORIDE (A-S Medication Solutions), LIDOCAINE HYDROCHLORIDE (Asclemed USA), LIDOCAINE HYDROCHLORIDE (Cardinal Health 107), LIDOCAINE HYDROCHLORIDE (Golden State Medical Supply), LIDOCAINE HYDROCHLORIDE (Henry Schein), LIDOCAINE HYDROCHLORIDE (Henry Schein), LIDOCAINE HYDROCHLORIDE (Henry Schein), LIDOCAINE HYDROCHLORIDE (Henry Schein), LIDOCAINE HYDROCHLORIDE (Henry Schein), LIDOCAINE HYDROCHLORIDE (Henry Schein), LIDOCAINE HYDROCHLORIDE (Henry Schein), LIDOCAINE HYDROCHLORIDE (Henry Schein), LIDOCAINE HYDROCHLORIDE (Hospira), LIDOCAINE HYDROCHLORIDE (Hospira), LIDOCAINE HYDROCHLORIDE (Hospira), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (Medical Purchasing Solutions), LIDOCAINE HYDROCHLORIDE (NuCare Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (Preferred Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (REMEDYREPACK), LIDOCAINE HYDROCHLORIDE (RPK Pharmaceuticals), LIDOCAINE HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), NA (SINTETICA SA), NA (Sintetica US LLC)
Formula
C14H22N2O. HCl. H2O
Exact mass
288.1605
Mol weight
288.8135
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01651  Class Ib antiarrhythmic agent
Neuropsychiatric agent
 DG02030  Anesthetics
  DG01675  Local anesthetic
   DG01673  Amide type local anesthetic
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1214
ATC code: C01BB01 C05AD01 D04AB01 N01BB02 R02AD02 S01HA07 S02DA01
Chemical structure group: DG00196
Product (DG00196): D00358<JP/US> D02086<JP/US> D08127<JP/US>
Product (mixture): D04813<JP/US>
Efficacy
Anesthetic (topical), Antiarrhythmic, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576]
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB01 Lidocaine
      D08127  Lidocaine hydrochloride monohydrate <JP/US>
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD01 Lidocaine
      D08127  Lidocaine hydrochloride monohydrate <JP/US>
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB01 Lidocaine
      D08127  Lidocaine hydrochloride monohydrate <JP/US>
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB02 Lidocaine
      D08127  Lidocaine hydrochloride monohydrate <JP/US>
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AD Anesthetics, local
     R02AD02 Lidocaine
      D08127  Lidocaine hydrochloride monohydrate <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA07 Lidocaine
      D08127  Lidocaine hydrochloride monohydrate <JP/US>
  S02 OTOLOGICALS
   S02D OTHER OTOLOGICALS
    S02DA Analgesics and anesthetics
     S02DA01 Lidocaine
      D08127  Lidocaine hydrochloride monohydrate <JP/US>
USP drug classification [BR:br08302]
 Anesthetics
  Local Anesthetics
   Lidocaine
    D08127  Lidocaine hydrochloride monohydrate
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1214  Xylidines
     D08127  Lidocaine hydrochloride monohydrate
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01651  Class Ib antiarrhythmic agent
     DG00196  Lidocaine
      D08127  Lidocaine hydrochloride monohydrate
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG01675  Local anesthetic
    DG01673  Amide type local anesthetic
     DG00196  Lidocaine
      D08127  Lidocaine hydrochloride monohydrate
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00196  Lidocaine
    D08127  Lidocaine hydrochloride monohydrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00196  Lidocaine
     D08127  Lidocaine hydrochloride monohydrate
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   D08127  Lidocaine hydrochloride monohydrate
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D08127  Lidocaine hydrochloride monohydrate <JP/US>
    SCN2A
     D08127  Lidocaine hydrochloride monohydrate <JP/US>
    SCN3A
     D08127  Lidocaine hydrochloride monohydrate <JP/US>
    SCN4A
     D08127  Lidocaine hydrochloride monohydrate <JP/US>
    SCN5A
     D08127  Lidocaine hydrochloride monohydrate <JP/US>
    SCN8A
     D08127  Lidocaine hydrochloride monohydrate <JP/US>
    SCN9A
     D08127  Lidocaine hydrochloride monohydrate <JP/US>
    SCN10A
     D08127  Lidocaine hydrochloride monohydrate <JP/US>
    SCN11A
     D08127  Lidocaine hydrochloride monohydrate <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08127
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01651  Class Ib antiarrhythmic agent
     DG00196  Lidocaine
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG01675  Local anesthetic
    DG01673  Amide type local anesthetic
     DG00196  Lidocaine
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00196  Lidocaine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00196  Lidocaine
Other DBs
CAS: 6108-05-0
PubChem: 96024817
ChEBI: 60791
LigandBox: D08127
LinkDB
KCF data

ATOM        19
            1   C8y C    19.5300  -17.9200
            2   N1b N    20.7200  -18.6200
            3   C8y C    18.2700  -18.6200
            4   C8y C    19.5300  -16.5200
            5   C5a C    21.9800  -17.9200
            6   C8x C    17.0800  -17.9200
            7   C1a C    18.2700  -20.0200
            8   C8x C    18.2700  -15.8200
            9   C1a C    20.7200  -15.8200
            10  C1b C    23.1700  -18.6200
            11  O5a O    21.9800  -16.8700
            12  C8x C    17.0800  -16.5200
            13  N1c N    24.4300  -17.9200
            14  C1b C    25.6900  -18.6200
            15  C1b C    24.4300  -16.5200
            16  C1a C    26.8800  -17.9200
            17  C1a C    25.6900  -15.8200
            18  X   Cl   31.2200  -17.3600
            19  O0  O    31.2900  -14.9100
BOND        17
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17    8  12 1

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