Entry |
|
Name |
Loxapine hydrochloride; Desconex (TN) |
Formula |
C18H18ClN3O. HCl
|
Exact mass |
363.0905
|
Mol weight |
364.269
|
Structure |
|
Simcomp |
|
Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
Remark |
Product (DG00897): | D02340<US> D00794<US> |
|
Efficacy |
Antipsychotic, Neuroleptic, Dopamine D2 receptor antagonist, Serotonin receptor antagonist |
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
|
Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565]
|
Interaction |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AH Diazepines, oxazepines, thiazepines and oxepines
N05AH01 Loxapine
D08148 Loxapine hydrochloride
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00897 Loxapine
D08148 Loxapine hydrochloride
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00897 Loxapine
D08148 Loxapine hydrochloride
DG01644 CYP2D6 substrate
DG00897 Loxapine
D08148 Loxapine hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00897 Loxapine
D08148 Loxapine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D08148 Loxapine hydrochloride
Serotonin
HTR2A
D08148 Loxapine hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08148
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00897 Loxapine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00897 Loxapine
DG01644 CYP2D6 substrate
DG00897 Loxapine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00897 Loxapine
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 24
1 C2y C 24.0800 -17.2200
2 C8y C 23.2400 -16.1000
3 C8y C 23.5900 -14.7700
4 O2x O 24.8500 -14.2100
5 N2x N 25.4800 -17.2200
6 C8y C 26.0400 -14.7700
7 C8y C 26.3900 -16.1700
8 C8x C 22.5400 -13.7900
9 C8x C 21.2100 -14.2100
10 C8y C 20.8600 -15.5400
11 C8x C 21.9100 -16.5200
12 C8x C 27.7200 -16.5900
13 C8x C 28.7700 -15.6800
14 C8x C 28.4200 -14.2800
15 C8x C 27.0900 -13.8600
16 X Cl 19.5300 -15.9600
17 N1y N 23.4500 -18.4800
18 C1x C 22.0500 -18.4800
19 C1x C 21.3500 -19.6700
20 N1y N 22.0500 -20.9300
21 C1x C 23.4500 -20.9300
22 C1x C 24.1500 -19.6700
23 C1a C 21.3500 -22.1200
24 X Cl 30.1700 -19.8800
BOND 26
1 3 4 1
2 1 5 2
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 10 16 1
19 1 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 17 22 1
26 20 23 1
|