| Entry |
|
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| Name |
Metronidazole benzoate (USP);
Elyzol (TN) |
|---|
| Formula |
C13H13N3O4
|
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| Exact mass |
275.0906
|
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| Mol weight |
275.26
|
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| Structure |
|
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| Class |
Antiparasitic
DG01884 Imidazole antiprotozoal
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
|
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| Remark |
| Product (DG00006): | D00409<JP/US> |
|
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| Efficacy |
Antibacterial, Antiprotozoal, DNA synthesis inhibitor |
|---|
| Comment |
Nitroimidazole derivative
|
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| Target |
DNA |
|---|
| Metabolism |
Enzyme: CYP2A6 [HSA: 1548]
|
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| Interaction |
CYP inhibition: CYP2C9 [HSA: 1559]
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AB Antiinfectives and antiseptics for local oral treatment
A01AB17 Metronidazole
D08214 Metronidazole benzoate (USP)
D DERMATOLOGICALS
D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
D06B CHEMOTHERAPEUTICS FOR TOPICAL USE
D06BX Other chemotherapeutics
D06BX01 Metronidazole
D08214 Metronidazole benzoate (USP)
G GENITO URINARY SYSTEM AND SEX HORMONES
G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
G01AF Imidazole derivatives
G01AF01 Metronidazole
D08214 Metronidazole benzoate (USP)
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01X OTHER ANTIBACTERIALS
J01XD Imidazole derivatives
J01XD01 Metronidazole
D08214 Metronidazole benzoate (USP)
P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
P01 ANTIPROTOZOALS
P01A AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES
P01AB Nitroimidazole derivatives
P01AB01 Metronidazole
D08214 Metronidazole benzoate (USP)
Drug groups [BR:br08330]
Antiparasitic
DG01884 Imidazole antiprotozoal
DG00006 Metronidazole
D08214 Metronidazole benzoate
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
DG00006 Metronidazole
D08214 Metronidazole benzoate
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
DG00006 Metronidazole
D08214 Metronidazole benzoate
Antimicrobials [BR:br08307]
Antibacterials
Bactericidal action
Imidazole
D08214 Metronidazole benzoate (USP)
Antiparasitics
Agents against Amebiasis and other antiprotozoals
Nitroimidazole derivatives
D08214 Metronidazole benzoate (USP)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08214
Drug groups [BR:br08330]
Antiparasitic
DG01884 Imidazole antiprotozoal
DG00006 Metronidazole
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
DG00006 Metronidazole
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
DG00006 Metronidazole
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Bactericidal action
Imidazole
DG00006 Metronidazole
|
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| Other DBs |
|
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| LinkDB |
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| KCF data |
ATOM 20
1 N4y N 23.5200 -17.2900
2 C8y C 23.1000 -18.5500
3 C8y C 22.4000 -16.4500
4 C1b C 24.5700 -16.6600
5 C8x C 21.7700 -18.5500
6 N2b N 23.8700 -19.6000 #+
7 N5x N 21.3500 -17.2900
8 C1a C 22.4000 -15.1200
9 C1b C 25.6900 -17.3600
10 O3a O 25.0600 -20.7900
11 O3a O 22.4000 -20.7900 #-
12 O7a O 26.9500 -16.6600
13 C7a C 28.1507 -17.3799
14 C8y C 29.3746 -16.7000
15 O6a O 28.1278 -18.7599
16 C8x C 30.6074 -17.4387
17 C8x C 31.8310 -16.7585
18 C8x C 31.8538 -15.3587
19 C8x C 30.6211 -14.6199
20 C8x C 29.3974 -15.3001
BOND 21
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 6 10 2
10 6 11 1
11 9 12 1
12 5 7 1
13 12 13 1
14 13 14 1
15 13 15 2
16 14 16 2
17 16 17 1
18 17 18 2
19 18 19 1
20 19 20 2
21 14 20 1
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