| Entry |
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| Name |
Mianserin (INN);
Tolvon (TN) |
|---|
| Formula |
C18H20N2
|
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| Exact mass |
264.1626
|
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| Mol weight |
264.3648
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
Neuropsychiatric agent
DG01729 Tetracyclic antidepressant
DG03077 Noradrenergic and specific serotonergic antidepressant (NaSSA)
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Product (DG00951): | D01358<JP> |
|
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| Efficacy |
Antidepressant |
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| Comment |
tetracyclic antidepressants
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP1A2 [HSA: 1544], CYP2D6 [HSA: 1565]
|
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AX Other antidepressants
N06AX03 Mianserin
D08216 Mianserin (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
DG00951 Mianserin
D08216 Mianserin
Neuropsychiatric agent
DG01729 Tetracyclic antidepressant
DG00951 Mianserin
D08216 Mianserin
DG03077 Noradrenergic and specific serotonergic antidepressant (NaSSA)
D08216 Mianserin
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00951 Mianserin
D08216 Mianserin
DG01644 CYP2D6 substrate
DG00951 Mianserin
D08216 Mianserin
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00951 Mianserin
D08216 Mianserin
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA2
D08216 Mianserin (INN)
Histamine
HRH1
D08216 Mianserin (INN)
Serotonin
HTR2A
D08216 Mianserin (INN)
HTR2C
D08216 Mianserin (INN)
Ion channels
Ligand-gated ion channels
Serotonin
HTR3
D08216 Mianserin (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08216
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
DG00951 Mianserin
Neuropsychiatric agent
DG01729 Tetracyclic antidepressant
DG00951 Mianserin
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00951 Mianserin
DG01644 CYP2D6 substrate
DG00951 Mianserin
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00951 Mianserin
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 20
1 C8y C 20.1600 -15.0500
2 N1y N 19.2500 -16.1000
3 C1y C 17.8500 -16.1000
4 C8y C 17.0100 -14.9800
5 C8y C 19.8800 -13.6500
6 C8y C 17.3600 -13.6500
7 C1x C 18.6200 -13.0200
8 C8x C 16.3800 -12.6700
9 C8x C 14.9800 -13.0900
10 C8x C 14.7000 -14.4200
11 C8x C 15.6800 -15.4000
12 C8x C 21.4900 -15.4700
13 C8x C 22.5400 -14.5600
14 C8x C 22.2600 -13.1600
15 C8x C 20.9300 -12.7400
16 C1x C 17.1500 -17.2900
17 N1y N 17.8500 -18.5500
18 C1x C 19.2500 -18.5500
19 C1x C 19.9500 -17.3600
20 C1a C 17.1500 -19.7400
BOND 23
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 6 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 4 11 2
13 1 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 5 15 2
18 3 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 2 19 1
23 17 20 1
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