| Entry |
|
|---|
| Name |
Perhexiline (INN) |
|---|
| Formula |
C19H35N
|
|---|
| Exact mass |
277.277
|
|---|
| Mol weight |
277.4879
|
|---|
| Structure |
|
|---|
| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
|
|---|
| Efficacy |
Vasodilator (coronary), Calcium channel blocker |
|---|
| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08E NON-SELECTIVE CALCIUM CHANNEL BLOCKERS
C08EX Other non-selective calcium channel blockers
C08EX02 Perhexiline
D08340 Perhexiline (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00334 Perhexiline
D08340 Perhexiline
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00334 Perhexiline
D08340 Perhexiline
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D08340 Perhexiline (INN)
Enzymes
Transferases (EC2)
Acyltransferases
CPT
D08340 Perhexiline (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08340
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00334 Perhexiline
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00334 Perhexiline
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 20
1 C1x C 20.5800 -19.3200
2 C1x C 20.5800 -20.7200
3 C1x C 21.7700 -21.4200
4 C1x C 22.9600 -20.7200
5 C1y C 22.9600 -19.3200
6 C1x C 21.7700 -18.6200
7 C1x C 25.4100 -20.7200
8 C1y C 25.4100 -19.3200
9 C1c C 24.1500 -18.6200
10 C1x C 26.6000 -21.4200
11 C1x C 27.7900 -20.7200
12 C1x C 27.7900 -19.3200
13 C1x C 26.6000 -18.6200
14 C1b C 24.1500 -17.2200
15 C1y C 25.4100 -16.5200
16 N1x N 26.6000 -17.2200
17 C1x C 27.7900 -16.5200
18 C1x C 27.7900 -15.1200
19 C1x C 26.6000 -14.4200
20 C1x C 25.4100 -15.1200
BOND 22
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 7 8 1
8 8 9 1
9 5 9 1
10 7 10 1
11 10 11 1
12 11 12 1
13 12 13 1
14 8 13 1
15 9 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 18 19 1
21 19 20 1
22 15 20 1
|
|---|
