| Entry |
|
|---|
| Name |
Perphenazine enantate;
Perphenazine enanthate;
Trilafon (TN) |
|---|
| Formula |
C28H38ClN3O2S
|
|---|
| Exact mass |
515.2373
|
|---|
| Mol weight |
516.1382
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Product (DG00875): | D00503<JP/US> D02037<JP> D04038<JP> D04965<JP> |
|
|---|
| Efficacy |
Antipsychotic, Neuroleptic, Dopamine D2 receptor antagonist |
|---|
| Comment |
Phenothiazine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AB Phenothiazines with piperazine structure
N05AB03 Perphenazine
D08342 Perphenazine enantate
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00875 Perphenazine
D08342 Perphenazine enantate
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00875 Perphenazine
D08342 Perphenazine enantate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00875 Perphenazine
D08342 Perphenazine enantate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D08342 Perphenazine enantate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08342
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00875 Perphenazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00875 Perphenazine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00875 Perphenazine
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 35
1 C8x C 11.5500 -19.3200
2 C8x C 11.5500 -20.7900
3 C8x C 12.7400 -21.4900
4 C8y C 13.9300 -20.7900
5 C8y C 13.9300 -19.3200
6 C8x C 12.7400 -18.6200
7 S2x S 15.1900 -21.4900
8 C8y C 16.3800 -20.7900
9 C8y C 16.3800 -19.3200
10 N4y N 15.1900 -18.6200
11 C8x C 17.5700 -21.4900
12 C8x C 18.8300 -20.7900
13 C8y C 18.8300 -19.3200
14 C8x C 17.5700 -18.6200
15 C1b C 15.1900 -17.2200
16 C1b C 16.3800 -16.5200
17 C1b C 17.5700 -17.2200
18 N1y N 18.7600 -16.5200
19 C1x C 19.9500 -17.2200
20 C1x C 21.2100 -16.5200
21 N1y N 21.2100 -15.1200
22 C1x C 20.0200 -14.4200
23 C1x C 18.7600 -15.1200
24 C1b C 22.4000 -14.4200
25 C1b C 23.6600 -15.1200
26 O7a O 24.7100 -14.4200
27 X Cl 20.0200 -18.6200
28 C7a C 25.9700 -15.1200
29 C1b C 27.1600 -14.4200
30 C1b C 28.3500 -15.1200
31 C1b C 29.6100 -14.4200
32 C1b C 30.8000 -15.1200
33 C1b C 31.9900 -14.4200
34 C1a C 33.1800 -15.1200
35 O6a O 25.9700 -16.5200
BOND 38
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 8 11 2
13 11 12 1
14 12 13 2
15 13 14 1
16 9 14 2
17 10 15 1
18 15 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 22 23 1
26 18 23 1
27 21 24 1
28 24 25 1
29 25 26 1
30 13 27 1
31 26 28 1
32 28 29 1
33 29 30 1
34 30 31 1
35 31 32 1
36 32 33 1
37 33 34 1
38 28 35 2
|
|---|
