| Entry |
|
|---|
| Name |
Propiverine (INN) |
|---|
| Formula |
C23H29NO3
|
|---|
| Exact mass |
367.2147
|
|---|
| Mol weight |
367.4813
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00479): | D01007<JP> |
|
|---|
| Efficacy |
Antipollakisuria, Overactive bladder agent, Muscarinic acetylcholine receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07220 | Cholinergic and anticholinergic drugs |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G04 UROLOGICALS
G04B UROLOGICALS
G04BD Drugs for urinary frequency and incontinence
G04BD06 Propiverine
D08441 Propiverine (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
DG00479 Propiverine
D08441 Propiverine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00479 Propiverine
D08441 Propiverine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM
D08441 Propiverine (INN)
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D08441 Propiverine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08441
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
DG00479 Propiverine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00479 Propiverine
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 27
1 C1x C 19.3200 -19.3200
2 N1y N 19.3200 -20.7200
3 C1x C 20.5100 -21.4200
4 C1x C 21.7700 -20.7200
5 C1y C 21.7700 -19.3200
6 C1x C 20.5100 -18.6200
7 O7a O 22.9600 -18.6200
8 C7a C 24.1500 -19.3200
9 C1d C 25.4100 -18.6200
10 C8y C 26.6000 -19.3200
11 C8x C 27.7900 -18.6200
12 C8x C 29.0500 -19.3200
13 C8y C 25.4100 -17.2200
14 C8x C 26.6000 -16.5200
15 C8x C 26.6000 -15.1200
16 C8x C 25.4100 -14.4200
17 C8x C 24.1500 -15.1200
18 C8x C 24.1500 -16.5200
19 C8x C 26.6000 -20.7200
20 C8x C 27.7900 -21.4200
21 C8x C 29.0500 -20.7200
22 O2a O 26.6000 -17.9200
23 C1b C 27.7900 -17.2200
24 C1b C 29.0500 -17.9200
25 C1a C 30.2400 -17.2200
26 O6a O 24.1500 -20.7200
27 C1a C 18.1300 -21.4200
BOND 29
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 5 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 10 11 1
12 11 12 2
13 9 13 1
14 13 14 1
15 14 15 2
16 15 16 1
17 16 17 2
18 17 18 1
19 13 18 2
20 10 19 2
21 19 20 1
22 20 21 2
23 21 12 1
24 9 22 1
25 22 23 1
26 23 24 1
27 24 25 1
28 8 26 2
29 2 27 1
|
|---|
