| Entry |
|
|---|
| Name |
Ramosetron (INN) |
|---|
| Formula |
C17H17N3O
|
|---|
| Exact mass |
279.1372
|
|---|
| Mol weight |
279.3364
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG01762 Antiemetic
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Product (DG01239): | D02016<JP> |
|
|---|
| Efficacy |
Anti-emetic, Serotonin 5-HT3 receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07211 | Serotonin receptor agonists/antagonists |
|
|---|
| Brite |
Drug groups [BR:br08330]
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG01239 Ramosetron
D08466 Ramosetron
DG01762 Antiemetic
DG01239 Ramosetron
D08466 Ramosetron
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01239 Ramosetron
D08466 Ramosetron
DG01644 CYP2D6 substrate
DG01239 Ramosetron
D08466 Ramosetron
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
Serotonin
HTR3
D08466 Ramosetron (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08466
Drug groups [BR:br08330]
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG01239 Ramosetron
DG01762 Antiemetic
DG01239 Ramosetron
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01239 Ramosetron
DG01644 CYP2D6 substrate
DG01239 Ramosetron
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 21
1 C1x C 23.1700 -17.0100
2 C1y C 23.1700 -18.4100
3 C5a C 24.3600 -19.1100
4 C8y C 25.6200 -18.4100
5 C8x C 25.6200 -17.0100
6 C1x C 21.9800 -16.3100
7 C8y C 20.7200 -17.0100
8 C8y C 20.7200 -18.4100
9 C1x C 21.9800 -19.1100
10 C8y C 26.9500 -18.8300
11 C8y C 27.7200 -17.7100
12 N4y N 26.9500 -16.5900
13 C8x C 27.5100 -20.0900
14 C8x C 28.9100 -20.3000
15 C8x C 29.6800 -19.1100
16 C8x C 29.1200 -17.8500
17 O5a O 24.3600 -20.5100
18 N5x N 19.3900 -16.5900
19 C8x C 18.6200 -17.7100
20 N4x N 19.3900 -18.8300
21 C1a C 27.6500 -15.3300
BOND 24
1 1 2 1
2 2 3 1 #Up
3 3 4 1
4 4 5 2
5 1 6 1
6 6 7 1
7 7 8 2
8 8 9 1
9 2 9 1
10 4 10 1
11 10 11 2
12 11 12 1
13 5 12 1
14 10 13 1
15 13 14 2
16 14 15 1
17 15 16 2
18 11 16 1
19 3 17 2
20 7 18 1
21 18 19 2
22 19 20 1
23 8 20 1
24 12 21 1
|
|---|
