Entry |
|
Name |
Promethazine hibenzate; Hiberna (TN) |
Formula |
C17H20N2S. C14H10O4
|
Exact mass |
526.1926
|
Mol weight |
526.6459
|
Structure |
|
Simcomp |
|
Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
Remark |
Therapeutic category: | 4413 |
Product (DG00385): | D00480<JP/US> D03290<JP> D08768<JP> |
|
Efficacy |
Antiallergic, Antiparkinsonian, H1 receptor antagonist |
Comment |
Phenothiazine derivative
|
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
hsa04750 | Inflammatory mediator regulation of TRP channels |
|
Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
Interaction |
|
Structure map |
map07029 | Antipsychotics - phenothiazines |
map07212 | Histamine H1 receptor antagonists |
map07213 | Dopamine receptor agonists/antagonists |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04AA Antihistamines for topical use
D04AA10 Promethazine
D08768 Promethazine hibenzate <JP>
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AD Phenothiazine derivatives
R06AD02 Promethazine
D08768 Promethazine hibenzate <JP>
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
44 Allergic agents
441 Antihistamines
4413 Phenothiazines
D08768 Promethazine hibenzate
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00385 Promethazine
D08768 Promethazine hibenzate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00385 Promethazine
D08768 Promethazine hibenzate
Drug classes [BR:br08332]
Anti-allergic agent
DG01482 Histamine receptor H1 antagonist
D08768 Promethazine hibenzate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D08768 Promethazine hibenzate <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08768
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00385 Promethazine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00385 Promethazine
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 38
1 N1y N 13.3578 -16.8634
2 C8y C 14.5975 -17.5618
3 C8y C 12.1647 -17.5618
4 C1b C 13.3578 -15.4492
5 C8y C 14.5975 -18.9703
6 C8x C 15.7906 -16.8634
7 C8y C 12.1647 -18.9703
8 C8x C 10.9658 -16.8634
9 C1c C 14.5626 -14.7623
10 S2x S 13.3578 -19.6627
11 C8x C 15.7906 -19.6627
12 C8x C 16.9954 -17.5618
13 C8x C 10.9658 -19.6627
14 C8x C 9.7261 -17.5618
15 N1c N 14.5626 -13.4411
16 C1a C 15.7557 -15.4492
17 C8x C 16.9954 -18.9703
18 C8x C 9.7261 -18.9703
19 C1a C 13.2240 -12.6671
20 C1a C 15.6975 -12.7020
21 C8x C 19.1083 -17.5688
22 C8x C 19.1083 -18.9687
23 C8x C 20.3206 -19.6686
24 C8x C 21.5330 -18.9687
25 C8y C 21.5330 -17.5688
26 C8y C 20.3206 -16.8689
27 C8x C 23.9576 -18.9687
28 C8y C 23.9576 -17.5688
29 C5a C 22.7453 -16.8689
30 C8x C 25.1700 -19.6686
31 C8y C 26.3823 -18.9687
32 C8x C 26.3823 -17.5688
33 C8x C 25.1700 -16.8689
34 O1a O 27.5987 -19.6709
35 O5a O 22.7453 -15.4690
36 C6a C 20.3206 -15.4692
37 O6a O 19.0915 -14.7593
38 O6a O 21.5161 -14.7788
BOND 41
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 5 10 1
10 5 11 1
11 6 12 2
12 7 13 1
13 8 14 2
14 9 15 1
15 9 16 1
16 11 17 2
17 13 18 2
18 15 19 1
19 15 20 1
20 7 10 1
21 12 17 1
22 14 18 1
23 21 22 2
24 22 23 1
25 23 24 2
26 24 25 1
27 25 26 2
28 21 26 1
29 27 28 2
30 28 29 1
31 25 29 1
32 27 30 1
33 30 31 2
34 31 32 1
35 32 33 2
36 28 33 1
37 31 34 1
38 29 35 2
39 26 36 1
40 36 37 2
41 36 38 1
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