| Entry |
|
|---|
| Name |
Choline fenofibrate (USAN/INN);
Trilipix (TN) |
|---|
| Product |
|
|---|
| Generic |
FENOFIBRIC ACID (Alembic Pharmaceuticals Limited), FENOFIBRIC ACID (Alembic Pharmaceuticals), FENOFIBRIC ACID (Amneal Pharmaceuticals of New York LLC), FENOFIBRIC ACID (Aurobindo Pharma Limited), FENOFIBRIC ACID (Leading Pharma), FENOFIBRIC ACID (Lupin Pharmaceuticals), FENOFIBRIC ACID (Macleods Pharmaceuticals Limited), FENOFIBRIC ACID (Micro Labs Limited), FENOFIBRIC ACID (Slate Run Pharmaceuticals), FENOFIBRIC ACID (TWi Pharmaceuticals), FENOFIBRIC ACID DELAYED-RELEASE (Graviti Pharmaceuticals Private Limited), FENOFIBRIC ACID DELAYED-RELEASE (Laurus Labs Limited) |
|---|
| Formula |
C17H14ClO4. C5H14NO
|
|---|
| Exact mass |
421.1656
|
|---|
| Mol weight |
421.9144
|
|---|
| Structure |
|
|---|
| Class |
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01733 PPAR alpha agonist
DG01547 Fibrate
Metabolizing enzyme substrate
DG02924 UGT substrate
|
|---|
| Remark |
| Product (DG01548): | D00565<JP/US> D08890<US> |
|
|---|
| Efficacy |
Antihyperlipidemic, Triglyceride synthesis inhibitor, Peroxisome proliferator-activated receptor (PPAR) alpha agonist |
|---|
| Disease |
Hypertriglyceridemia [DS: H01637] Primary hypercholesterolemia or mixed dyslipidemia [DS: H01635] |
|---|
| Comment |
Clofibrate derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04920 | Adipocytokine signaling pathway |
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C10 LIPID MODIFYING AGENTS
C10A LIPID MODIFYING AGENTS, PLAIN
C10AB Fibrates
C10AB11 Choline fenofibrate
D08890 Choline fenofibrate (USAN/INN) <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Dyslipidemics, Fibric Acid Derivatives
Choline Fenofibrate
D08890 Choline fenofibrate (USAN/INN)
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01733 PPAR alpha agonist
DG01547 Fibrate
DG01548 Fenofibrate
D08890 Choline fenofibrate
Metabolizing enzyme substrate
DG02924 UGT substrate
DG01548 Fenofibrate
D08890 Choline fenofibrate
Drug classes [BR:br08332]
Cardiovascular agent
DG01946 Hypolipidemic agent
D08890 Choline fenofibrate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Thyroid hormone like receptors
Peroxisome proliferator-activated receptor (PPAR)
NR1C1 (PPARA)
D08890 Choline fenofibrate (USAN/INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08890
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01733 PPAR alpha agonist
DG01547 Fibrate
DG01548 Fenofibrate
Metabolizing enzyme substrate
DG02924 UGT substrate
DG01548 Fenofibrate
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 29
1 C8y C 18.3598 -16.7433
2 C5a C 17.1689 -17.4439
3 C8x C 19.6208 -17.4439
4 C8x C 18.3598 -15.3422
5 C8y C 15.9779 -16.7433
6 O5a O 17.1689 -18.8450
7 C8x C 20.8118 -16.7433
8 C8x C 19.6208 -14.6417
9 C8x C 14.7169 -17.4439
10 C8x C 15.9779 -15.3422
11 C8y C 20.8118 -15.3422
12 C8x C 13.5260 -16.7433
13 C8x C 14.7169 -14.6417
14 O2a O 22.0027 -14.6417
15 C8y C 13.5260 -15.3422
16 C1d C 23.2637 -15.3422
17 X Cl 12.3350 -14.6417
18 C6a C 24.4547 -14.6417
19 O6a O 25.6456 -15.3422 #-
20 O6a O 24.4547 -13.2406
21 C1a C 22.5632 -16.5332
22 C1a C 23.9643 -16.5332
23 C1a C 29.8900 -16.7300
24 N1d N 31.0800 -16.0300 #+
25 C1b C 32.3400 -16.7300
26 C1b C 33.5300 -16.0300
27 O1a O 34.7200 -16.7300
28 C1a C 31.0800 -14.6300
29 C1a C 31.0800 -17.4300
BOND 29
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 1
7 4 8 2
8 5 9 2
9 5 10 1
10 7 11 2
11 9 12 1
12 10 13 2
13 11 14 1
14 12 15 2
15 14 16 1
16 15 17 1
17 16 18 1
18 18 19 1
19 18 20 2
20 8 11 1
21 13 15 1
22 16 21 1
23 16 22 1
24 23 24 1
25 24 25 1
26 25 26 1
27 26 27 1
28 24 28 1
29 24 29 1
|
|---|
