KEGG   DRUG: Estradiol and norethindrone
Entry
D09188            Mixture   Drug                                   
Name
Estradiol and norethindrone;
Menoaid (TN);
Activella (TN);
Combipatch (TN);
Estradiol and norethindrone acetate (TN)
Product
ACTIVELLA (Amneal Pharmaceuticals LLC), COMBIPATCH (ESTRADIOL/NORETHINDRONE ACETATE TRANSDERMAL SYSTEM) (Noven Therapeutics), LOPREEZA (Amneal Pharmaceuticals NY LLC)
  Generic
AMABELZ (Lupin Pharmaceuticals), ESTRADIOL / NORETHINDRONE ACETATE (Breckenridge Pharmaceutical), ESTRADIOL AND NORETHINDRONE ACETATE (Ingenus Pharmaceuticals), ESTRADIOL AND NORETHINDRONE ACETATE (Mylan Pharmaceuticals), ETYQA (Aurobindo Pharma Limited), LOPREEZA (Amneal Pharmaceuticals NY LLC), MIMVEY (Teva Pharmaceuticals USA)
Component
Estradiol [DR:D00105], (Norethisterone acetate [DR:D00953] | Norethindrone [DR:D00182])
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2482
ATC code: G03FA01 G03FB05
Product: D09188<JP/US>
Efficacy
Replenisher (hormone)
Comment
Estradiol is primarily metabolized by CYP3A4.
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03F PROGESTOGENS AND ESTROGENS IN COMBINATION
    G03FA Progestogens and estrogens, fixed combinations
     G03FA01 Norethisterone and estrogen
      D09188  Estradiol and norethindrone <JP/US>
    G03FB Progestogens and estrogens, sequential preparations
     G03FB05 Norethisterone and estrogen
      D09188  Estradiol and norethindrone <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers), Other
   Estradiol/ Norethindrone Acetate
    D09188  Estradiol and norethindrone
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   248  Mixed hormone preparations
    2482  Estrogens and progestins
     D09188  Estradiol and norethindrone
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D09188  Estradiol and norethindrone
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09188
Other DBs
PubChem: 96025868
LinkDB

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