KEGG   DRUG: Palovarotene
Entry
D09365                      Drug                                   
Name
Palovarotene (JAN/USAN/INN);
Sohonos (TN)
Product
SOHONOS (Ipsen Biopharmaceuticals)
Formula
C27H30N2O2
Exact mass
414.2307
Mol weight
414.5393
Structure
Class
Vitamin and mineral
 DG01604  Retinol derivative
Metabolizing enzyme substrate
 DG02918  CYP2C8 substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: M09AX11
Product: D09365<US>
Efficacy
Retinoic acid receptor gamma agonist
  Disease
Fibrodysplasia ossificans progressiva [DS:H00430]
Comment
Treatment of emphysema
Prevention of heterotopic ossification in patients with fibrodysplasia (myositis) ossificans progressiva (FOP)
Target
NR1B3 (RARG) [HSA:5916] [KO:K08529]
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2C8 [HSA:1558], CYP2C19 [HSA:1557]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M09 OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
   M09A OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
    M09AX Other drugs for disorders of the musculo-skeletal system
     M09AX11 Palovarotene
      D09365  Palovarotene (JAN/USAN/INN) <US>
USP drug classification [BR:br08302]
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Palovarotene
   D09365  Palovarotene (JAN/USAN/INN)
Drug groups [BR:br08330]
 Vitamin and mineral
  DG01604  Retinol derivative
   D09365  Palovarotene
 Metabolizing enzyme substrate
  DG02918  CYP2C8 substrate
   D09365  Palovarotene
  DG01639  CYP2C19 substrate
   D09365  Palovarotene
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D09365  Palovarotene
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Retinoic acid receptor (RAR)
    NR1B3 (RARG)
     D09365  Palovarotene (JAN/USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09365
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09365
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09365
Other DBs
CAS: 410528-02-8
PubChem: 96026045
ChEBI: 188559
LigandBox: D09365
LinkDB
KCF data

ATOM        31
            1   C8y C    19.1100  -22.5400
            2   C8y C    19.1100  -23.9400
            3   C8x C    20.3224  -24.6400
            4   C8y C    21.5349  -23.9400
            5   C8y C    21.5349  -22.5400
            6   C8x C    20.3224  -21.8400
            7   C1z C    17.8976  -21.8400
            8   C1x C    16.6851  -22.5400
            9   C1x C    16.6851  -23.9400
            10  C1z C    17.8976  -24.6400
            11  C1a C    18.5976  -20.6276
            12  C1a C    17.1976  -20.6276
            13  C1a C    17.1976  -25.8524
            14  C1a C    18.5976  -25.8524
            15  C2b C    22.7660  -21.8290
            16  C1b C    22.7660  -24.6510
            17  C2b C    23.9712  -22.5247
            18  C8y C    25.1535  -21.8419
            19  C8x C    26.3475  -22.5312
            20  C8x C    27.5599  -21.8312
            21  C8y C    27.5599  -20.4312
            22  C8x C    26.3659  -19.7418
            23  C8x C    25.1535  -20.4419
            24  C6a C    28.7834  -19.7246
            25  O6a O    29.9924  -20.4225
            26  O6a O    28.7831  -18.3401
            27  N4y N    22.7660  -26.0510
            28  C8x C    21.6283  -26.8777
            29  C8x C    22.0630  -28.2152
            30  C8x C    23.4693  -28.2151
            31  N5x N    23.9038  -26.8776
BOND        34
            1     2   3 1
            2     3   4 2
            3     4   5 1
            4     5   6 2
            5     1   6 1
            6     1   7 1
            7     7   8 1
            8     8   9 1
            9     9  10 1
            10    2  10 1
            11    1   2 2
            12    7  11 1
            13    7  12 1
            14   10  13 1
            15   10  14 1
            16    5  15 1
            17    4  16 1
            18   15  17 2
            19   17  18 1
            20   18  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   22  23 1
            25   18  23 2
            26   21  24 1
            27   24  25 1
            28   24  26 2
            29   16  27 1
            30   27  28 1
            31   28  29 2
            32   29  30 1
            33   30  31 2
            34   27  31 1

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