KEGG   DRUG: Olaparib
Entry
D09730                      Drug                                   
Name
Olaparib (JAN/USAN/INN);
Lynparza (TN)
Product
LYNPARZA (AstraZeneca Pharmaceuticals LP)
Formula
C24H23FN4O3
Exact mass
434.1754
Mol weight
434.4628
Structure
Class
Antineoplastic
 DG02942  PARP inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Therapeutic category: 4291
ATC code: L01XK01
Product: D09730<JP/US>
Efficacy
Antineoplastic, PARP inhibitor
  Disease
Ovarian cancer [DS:H00027]
Ovarian cancer (BRCA-mutated) [DS:H00027]
Ovarian cancer (HRD-positive) [DS:H00027]
Breast cancer (BRCA-mutated, HER2-negative) [DS:H00031]
Pancreatic adenocarcinoma (BRCA-mutated) [DS:H00019]
Prostate cancer, castration-resistant (HRR gene-mutated) [DS:H00024]
Prostate cancer, castration-resistant (BRCA-mutated) [DS:H00024]
Comment
PARP inhibition in BRCA1 [HSA:672] [KO:K10605] and BRCA2 [HSA:675] [KO:K08775] -mutation
Target
PARP1 [HSA:142] [KO:K24070]
PARP2 [HSA:10038] [KO:K10798]
  Pathway
hsa03410  Base excision repair
hsa04064  NF-kappa B signaling pathway
hsa04210  Apoptosis
hsa04217  Necroptosis
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Other map
map04212  Longevity regulating pathway - worm
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XK Poly (ADP-ribose) polymerase (PARP) inhibitors
     L01XK01 Olaparib
      D09730  Olaparib (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Olaparib
    D09730  Olaparib (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D09730  Olaparib (JAN/USAN/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG02942  PARP inhibitor
   D09730  Olaparib
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D09730  Olaparib
Drug classes [BR:br08332]
 Antineoplastic
  DG02942  PARP inhibitor
   D09730  Olaparib
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Pentosyltransferases
    PARP1
     D09730  Olaparib (JAN/USAN/INN) <JP/US>
    PARP2
     D09730  Olaparib (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09730
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09730
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09730
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09730
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09730
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D09730
Other DBs
CAS: 763113-22-0
PubChem: 124490470
ChEBI: 83766
PDB-CCD: 09L[PDBj]
LigandBox: D09730
LinkDB
KCF data

ATOM        32
            1   C8x C    14.9800  -23.2400
            2   C8x C    14.9800  -21.8400
            3   C8x C    16.1700  -21.1400
            4   C8y C    17.4300  -21.8400
            5   C8y C    17.4300  -23.2400
            6   C8x C    16.1700  -23.9400
            7   C8y C    18.6200  -21.1400
            8   N5x N    19.8100  -21.8400
            9   N4x N    19.8100  -23.2400
            10  C8y C    18.6200  -23.9400
            11  O5x O    18.6200  -25.3400
            12  C1b C    18.6200  -19.7400
            13  C8y C    19.8100  -19.0400
            14  C8x C    19.8100  -17.6400
            15  C8x C    21.0700  -16.9400
            16  C8y C    22.2600  -17.6400
            17  C8y C    22.2600  -19.0400
            18  C8x C    21.0700  -19.7400
            19  X   F    23.4500  -16.9400
            20  C5a C    23.4500  -19.7400
            21  N1y N    24.6400  -19.0400
            22  O5a O    23.4500  -21.1400
            23  C1x C    24.6400  -17.6400
            24  C1x C    25.9000  -16.9400
            25  N1y N    27.0900  -17.6400
            26  C1x C    27.0900  -19.0400
            27  C1x C    25.9000  -19.7400
            28  C5a C    28.2800  -16.9400
            29  C1y C    29.4700  -17.6400
            30  O5a O    28.2800  -15.5400
            31  C1x C    30.8700  -17.6400
            32  C1x C    30.1700  -18.8300
BOND        36
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12   10  11 2
            13    7  12 1
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   13  18 1
            21   16  19 1
            22   17  20 1
            23   20  21 1
            24   20  22 2
            25   21  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   21  27 1
            31   25  28 1
            32   28  29 1
            33   28  30 2
            34   29  31 1
            35   31  32 1
            36   32  29 1

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