KEGG   DRUG: Vardenafil hydrochloride
Entry
D09989                      Drug                                   
Name
Vardenafil hydrochloride (USP)
Formula
C23H32N6O4S. HCl
Exact mass
524.1973
Mol weight
525.0639
Structure
Simcomp
Class
Cardiovascular agent
 DG01509  Phosphodiesterase V inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: G04BE09
Chemical structure group: DG00487
Product (DG00487): D03260<JP/US>
Efficacy
Vasodilator, Impotence therapy, Phosphodiesterase V inhibitor
Comment
Treatment of erectile dysfunction
Target
PDE5 [HSA:8654] [KO:K13762]
  Pathway
hsa04022  cGMP-PKG signaling pathway
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BE Drugs used in erectile dysfunction
     G04BE09 Vardenafil
      D09989  Vardenafil hydrochloride (USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01509  Phosphodiesterase V inhibitor
   DG00487  Vardenafil
    D09989  Vardenafil hydrochloride
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00487  Vardenafil
     D09989  Vardenafil hydrochloride
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Phosphodiesterases
    PDE5
     D09989  Vardenafil hydrochloride (USP)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09989
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09989
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01509  Phosphodiesterase V inhibitor
   DG00487  Vardenafil
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00487  Vardenafil
Other DBs
CAS: 224785-91-5
PubChem: 135626710
LigandBox: D09989
LinkDB
KCF data

ATOM        35
            1   C8y C    28.7700  -28.2800
            2   C8y C    29.9600  -27.5800
            3   C8y C    28.7700  -29.6800
            4   C8x C    27.5100  -27.5800
            5   N4x N    31.1500  -28.2800
            6   N5x N    29.9600  -26.1800
            7   C8x C    27.5100  -30.3800
            8   O2a O    29.9600  -30.3800
            9   C8y C    26.3200  -28.2800
            10  N4y N    32.4100  -27.5800
            11  C8y C    31.1500  -25.4800
            12  C8x C    26.3200  -29.6800
            13  C1b C    31.1500  -29.6800
            14  S4a S    25.1300  -27.5800
            15  C8y C    32.4100  -26.1800
            16  C8y C    33.7400  -28.0000
            17  O5x O    31.1500  -24.0100
            18  C1a C    32.3400  -30.3800
            19  N1y N    23.9400  -28.2800
            20  O3c O    26.1100  -26.6000
            21  O3c O    24.1500  -26.6000
            22  C8y C    33.7400  -25.7600
            23  N5x N    34.5800  -26.8800
            24  C1b C    34.1600  -29.3300
            25  C1x C    23.9400  -29.6800
            26  C1x C    22.6800  -27.5800
            27  C1a C    34.1600  -24.4300
            28  C1b C    35.4900  -29.6100
            29  C1x C    22.6800  -30.3800
            30  C1x C    21.4900  -28.2800
            31  C1a C    35.9100  -30.9400
            32  N1y N    21.4900  -29.6800
            33  C1b C    20.3000  -30.3800
            34  C1a C    19.1100  -29.6800
            35  X   Cl   38.2200  -26.8100
BOND        37
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 1
            13    9  14 1
            14   10  15 1
            15   10  16 1
            16   11  17 2
            17   13  18 1
            18   14  19 1
            19   14  20 2
            20   14  21 2
            21   15  22 2
            22   16  23 2
            23   16  24 1
            24   19  25 1
            25   19  26 1
            26   22  27 1
            27   24  28 1
            28   25  29 1
            29   26  30 1
            30   28  31 1
            31   29  32 1
            32   32  33 1
            33    9  12 2
            34   11  15 1
            35   22  23 1
            36   30  32 1
            37   33  34 1

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