KEGG   DRUG: Ezetimibe and simvastatin
Entry
D10257            Mixture   Drug                                   
Name
Ezetimibe and simvastatin;
Vytorin (TN)
Product
VYTORIN (Organon LLC)
  Generic
EZETIMIBE AND SIMVASTATIN (A-S Medication Solutions), EZETIMIBE AND SIMVASTATIN (A-S Medication Solutions), EZETIMIBE AND SIMVASTATIN (Actavis Pharma), EZETIMIBE AND SIMVASTATIN (Amneal Pharmaceuticals NY LLC), EZETIMIBE AND SIMVASTATIN (Amneal Pharmaceuticals NY LLC), EZETIMIBE AND SIMVASTATIN (Ascend Laboratories), EZETIMIBE AND SIMVASTATIN (AvKARE), EZETIMIBE AND SIMVASTATIN (Dr.Reddys Laboratories), EZETIMIBE AND SIMVASTATIN (Glenmark Pharmaceuticals), EZETIMIBE AND SIMVASTATIN (Golden State Medical Supply), EZETIMIBE AND SIMVASTATIN (Golden State Medical Supply), EZETIMIBE AND SIMVASTATIN (NORTHSTAR RX LLC), EZETIMIBE AND SIMVASTATIN (REMEDYREPACK)
Component
Ezetimibe [DR:D01966], Simvastatin [DR:D00434]
Class
Transporter substrate
 DG02856  SLCO1B1 substrate
Remark
ATC code: C10BA02
Product: D10257<US>
Efficacy
Antihyperlipidemic
  Disease
Hyperlipidemia [DS:H01635]
Homozygous familial hypercholesterolemia [DS:H00155]
Comment
Simvastatin is a substrate for OATP1B1.
Metabolism
Transporter: SLCO1B1 [HSA:10599]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10B LIPID MODIFYING AGENTS, COMBINATIONS
    C10BA Combinations of various lipid modifying agents
     C10BA02 Simvastatin and ezetimibe
      D10257  Ezetimibe and simvastatin <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Cardiovascular Agents, Combinations
   Ezetimibe/ Simvastatin
    D10257  Ezetimibe and simvastatin
Drug groups [BR:br08330]
 Transporter substrate
  DG02856  SLCO1B1 substrate
   D10257  Ezetimibe and simvastatin
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D10257
Other DBs
PubChem: 163312288
LinkDB

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