KEGG   DRUG: Carbidopa, levodopa and entacapone
Entry
D10293            Mixture   Drug                                   
Name
Carbidopa, levodopa and entacapone;
Stalevo (TN)
Product
STALEVO (Almatica Pharma LLC)
  Generic
CARBIDOPA, LEVODOPA AND ENTACAPONE (Rising Pharma Holdings), CARBIDOPA, LEVODOPA AND ENTACAPONE (Wockhardt USA LLC.), CARBIDOPA, LEVODOPA, AND ENTACAPONE (Sandoz)
Component
Carbidopa hydrate [DR:D00558], Levodopa [DR:D00059], Entacapone [DR:D00781]
Class
Neuropsychiatric agent
 DG01967  Antiparkinson agent
  DG02909  COMT inhibitor
Metabolizing enzyme inhibitor
 DG01643  CYP2C9 inhibitor
Remark
Therapeutic category: 1169
ATC code: N04BA03
Product: D10293<JP/US>
Efficacy
Antiparkinsonian
  Disease
Parkinson disease [DS:H00057]
Comment
Entacapone is an inhibitor of COMT and CYP2C9.
Interaction
CYP inhibition: CYP2C9 [HSA:1559]
Enzyme inhibition: COMT [HSA:1312]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BA Dopa and dopa derivatives
     N04BA03 Levodopa, decarboxylase inhibitor and COMT inhibitor
      D10293  Carbidopa, levodopa and entacapone <JP/US>
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Antiparkinson Agents, Other
   Carbidopa/ Entacapone/ Levodopa
    D10293  Carbidopa, levodopa and entacapone
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1169  Others
     D10293  Carbidopa, levodopa and entacapone
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01967  Antiparkinson agent
   DG02909  COMT inhibitor
    D10293  Carbidopa, levodopa and entacapone
 Metabolizing enzyme inhibitor
  DG01643  CYP2C9 inhibitor
   D10293  Carbidopa, levodopa and entacapone
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG01967  Antiparkinson agent
   D10293  Carbidopa, levodopa and entacapone
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10293
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10293
Other DBs
PubChem: 163312324
LinkDB

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