KEGG   DRUG: Naloxegol oxalate
Entry
D10375                      Drug                                   
Name
Naloxegol oxalate (USAN);
Movantik (TN);
Moventig (TN)
Product
MOVANTIK (Quality Care Products), MOVANTIK (RedHill Biopharma), MOVANTIK (Valinor Pharma)
Formula
C34H53NO11. C2H2O4
Exact mass
741.3572
Mol weight
741.8196
Structure
Simcomp
Class
Analgesic
 DG01586  Opioid receptor antagonist
Gastrointestinal agent
 DG01770  Laxative
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
ATC code: A06AH03
Chemical structure group: DG00078
Product (DG00078): D10375<US>
Efficacy
Laxative, Opioid receptor antagonist
Comment
Treatment of opioid-induced constipation
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A06 DRUGS FOR CONSTIPATION
   A06A DRUGS FOR CONSTIPATION
    A06AH Peripheral opioid receptor antagonists
     A06AH03 Naloxegol
      D10375  Naloxegol oxalate (USAN) <US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Anti-constipation Agents
   Naloxegol
    D10375  Naloxegol oxalate (USAN)
Drug groups [BR:br08330]
 Analgesic
  DG01586  Opioid receptor antagonist
   DG00078  Naloxegol
    D10375  Naloxegol oxalate
 Gastrointestinal agent
  DG01770  Laxative
   DG00078  Naloxegol
    D10375  Naloxegol oxalate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00078  Naloxegol
    D10375  Naloxegol oxalate
Drug classes [BR:br08332]
 Gastrointestinal agent
  DG01770  Laxative
   D10375  Naloxegol oxalate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D10375  Naloxegol oxalate (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10375
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10375
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10375
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10375
Drug groups [BR:br08330]
 Analgesic
  DG01586  Opioid receptor antagonist
   DG00078  Naloxegol
 Gastrointestinal agent
  DG01770  Laxative
   DG00078  Naloxegol
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00078  Naloxegol
Other DBs
CAS: 1354744-91-4
PubChem: 172232468
LinkDB
KCF data

ATOM        52
            1   O6a O    24.7100   -5.1800
            2   C6a C    25.9224   -5.8800
            3   C6a C    27.1349   -5.1800
            4   O6a O    28.3473   -5.8800
            5   O6a O    25.9224   -7.2798
            6   O6a O    27.1349   -3.7802
            7   C8y C    12.9500   -4.3400
            8   C8y C    12.9500   -5.7400
            9   C8y C    14.1624   -6.4400
            10  C8y C    15.3749   -5.7400
            11  C8x C    15.3749   -4.3400
            12  C8x C    14.1624   -3.6400
            13  C1z C    14.1624   -7.8400
            14  C1z C    15.3749   -8.5400
            15  C1y C    16.5873   -7.8400
            16  C1x C    16.5873   -6.4400
            17  C1y C    12.9500   -8.5400
            18  C1y C    12.9500   -9.9400
            19  C1x C    14.1624  -10.6400
            20  C1x C    15.3749   -9.9400
            21  O2x O    11.9700   -7.0924
            22  O1a O    11.7376   -3.6400
            23  O1a O    16.5873   -9.2400
            24  C1x C    15.3749   -7.1400
            25  N1y N    17.8018   -8.5412
            26  C1x C    17.8018   -7.1412
            27  C1b C    19.2018   -8.5412
            28  C2b C    19.8956   -9.7433
            29  C2a C    21.2799   -9.7433
            30  O2a O    11.7376  -10.6400
            31  C1b C    11.7376  -12.0400
            32  C1b C    12.9667  -12.7498
            33  O2a O    14.1707  -12.0546
            34  C1b C    15.3538  -12.7377
            35  C1b C    16.5473  -12.0484
            36  O2a O    17.7356  -12.7345
            37  C1b C    18.9264  -12.0469
            38  C1b C    20.1160  -12.7337
            39  O2a O    21.3061  -12.0464
            40  C1b C    22.4962  -12.7335
            41  C1b C    23.6861  -12.0463
            42  O2a O    24.8762  -12.7334
            43  C1b C    26.0661  -12.0463
            44  C1b C    27.2562  -12.7334
            45  O2a O    28.4461  -12.0463
            46  C1b C    29.6362  -12.7334
            47  C1b C    30.8261  -12.0463
            48  O2a O    30.8261  -10.6463
            49  C1b C    29.5914   -9.9335
            50  C1b C    28.3902  -10.6271
            51  O2a O    27.2057   -9.9433
            52  C1a C    26.0130  -10.6321
BOND        55
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     2   5 2
            5     3   6 2
            6     7   8 2
            7     8   9 1
            8     9  10 2
            9    10  11 1
            10   11  12 2
            11    7  12 1
            12    9  13 1
            13   13  14 1
            14   14  15 1
            15   15  16 1
            16   10  16 1
            17   13  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   14  20 1
            22    8  21 1
            23   17  21 1 #Down
            24    7  22 1
            25   14  23 1 #Up
            26   13  24 1 #Up
            27   15  25 1 #Up
            28   25  26 1
            29   24  26 1
            30   25  27 1
            31   27  28 1
            32   28  29 2
            33   18  30 1 #Down
            34   30  31 1
            35   31  32 1
            36   32  33 1
            37   33  34 1
            38   34  35 1
            39   35  36 1
            40   36  37 1
            41   37  38 1
            42   38  39 1
            43   39  40 1
            44   40  41 1
            45   41  42 1
            46   42  43 1
            47   43  44 1
            48   44  45 1
            49   45  46 1
            50   46  47 1
            51   47  48 1
            52   48  49 1
            53   49  50 1
            54   50  51 1
            55   51  52 1

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