KEGG   DRUG: Ezetimibe and atorvastatin
Entry
D10385            Mixture   Drug                                   
Name
Ezetimibe and atorvastatin;
Atozet (TN);
Liptruzet (TN)
Product
  Generic
LYPQOZET (Althera Pharmaceuticals)
Component
Ezetimibe [DR:D01966], (Atorvastatin calcium [DR:D02258] | Atorvastatin calcium anhydorous [DR:D00887] | Atorvastatin [DR:D07474])
Class
Hypolipidemic agent
 DG01946  Hypolipidemic agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2189
ATC code: C10BA05
Product: D10385<JP/US>
Efficacy
Antihyperlipidemic
Comment
Antihypercholesterolemia
Atorvastatin is metabolized by CYP3A4.
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10B LIPID MODIFYING AGENTS, COMBINATIONS
    C10BA Combinations of various lipid modifying agents
     C10BA05 Atorvastatin and ezetimibe
      D10385  Ezetimibe and atorvastatin <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2189  Others
     D10385  Ezetimibe and atorvastatin
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   D10385  Ezetimibe and atorvastatin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D10385  Ezetimibe and atorvastatin
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01946  Hypolipidemic agent
   D10385  Ezetimibe and atorvastatin
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10385
Other DBs
PubChem: 172232478
LinkDB

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