| Entry |
|
|---|
| Name |
Ripasudil hydrochloride hydrate (JAN);
Glanatec (TN) |
|---|
| Formula |
C15H18FN3O2S. HCl. 2H2O
|
|---|
| Exact mass |
395.1082
|
|---|
| Mol weight |
395.8772
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
|
|---|
| Remark |
| Therapeutic category: | 1319 |
| Product (mixture): | D12437<JP> |
|
|---|
| Efficacy |
Antiglaucoma, Rho-associated kinase inhibitor |
|---|
| Target |
|
|---|
| Pathway |
| hsa04270 | Vascular smooth muscle contraction |
| hsa04670 | Leukocyte transendothelial migration |
| hsa04810 | Regulation of actin cytoskeleton |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EX Other antiglaucoma preparations
S01EX07 Ripasudil
D10463 Ripasudil hydrochloride hydrate (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1319 Others
D10463 Ripasudil hydrochloride hydrate (JAN)
Drug groups [BR:br08330]
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
D10463 Ripasudil hydrochloride hydrate
Drug classes [BR:br08332]
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
D10463 Ripasudil hydrochloride hydrate
Target-based classification of drugs [BR:br08310]
Protein kinases
Serine/threonine kinases
AGC group
ROCK
D10463 Ripasudil hydrochloride hydrate (JAN) <JP>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D10463
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 25
1 C1x C 18.9000 -15.4700
2 C1x C 18.0600 -14.3500
3 C1x C 18.3400 -12.9500
4 N1x N 19.6700 -12.3900
5 N1y N 20.3000 -15.4700
6 C1x C 20.8600 -13.0200
7 C1y C 21.2100 -14.3500
8 S4a S 20.3000 -16.8700
9 C8y C 20.3000 -18.2700
10 O3c O 21.7000 -16.8700
11 O3c O 18.9000 -16.8700
12 C8x C 19.1100 -18.9700
13 C8x C 19.1100 -20.3700
14 C8x C 20.3000 -21.0700
15 C8y C 21.4900 -20.3700
16 C8y C 21.4900 -18.9700
17 C8x C 22.7500 -21.0700
18 N5x N 23.9400 -20.3700
19 C8x C 23.9400 -18.9700
20 C8y C 22.7500 -18.2700
21 C1a C 22.5785 -14.6453
22 X F 22.7672 -16.8701
23 X Cl 26.2500 -16.5900
24 O0 O 26.7400 -18.3400
25 O0 O 26.7400 -19.6700
BOND 24
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 5 8 1
9 8 9 1
10 8 10 2
11 8 11 2
12 9 12 2
13 12 13 1
14 13 14 2
15 14 15 1
16 15 16 2
17 9 16 1
18 15 17 1
19 17 18 2
20 18 19 1
21 19 20 2
22 16 20 1
23 7 21 1 #Down
24 20 22 1
|
|---|
