KEGG   DRUG: Lusutrombopag
Entry
D10476                      Drug                                   
Name
Lusutrombopag (JAN/USAN/INN);
Mulpleta (TN)
Product
MULPLETA (SHIONOGI)
Formula
C29H32Cl2N2O5S
Exact mass
590.1409
Mol weight
591.5458
Structure
Class
Metabolizing enzyme substrate
 DG02978  CYP4A11 substrate
Remark
Therapeutic category: 3399
ATC code: B02BX07
Product: D10476<JP/US>
Efficacy
Antithrombocytopenia, Thrombopoietin receptor agonist
  Disease
Thrombocytopenia [DS:H00978]
Target
MPL (TPOR, CD110) [HSA:4352] [KO:K05082]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
Metabolism
Enzyme: CYP4A11 [HSA:1579]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BX Other systemic hemostatics
     B02BX07 Lusutrombopag
      D10476  Lusutrombopag (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Blood Products and Modifiers, Other
   Blood Products and Modifiers, Micellaneous
    Lusutrombopag
     D10476  Lusutrombopag (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D10476  Lusutrombopag (JAN/USAN/INN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02978  CYP4A11 substrate
   D10476  Lusutrombopag
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    MPL (TPOR, CD110)
     D10476  Lusutrombopag (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10476
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10476
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10476
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10476
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10476
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D10476
Other DBs
CAS: 1110766-97-6
PubChem: 172232569
LinkDB
KCF data

ATOM        39
            1   C8y C    13.5100  -30.7300
            2   N5x N    14.9100  -30.7300
            3   C8y C    15.3300  -29.4000
            4   S2x S    14.2100  -28.5600
            5   C8x C    13.0900  -29.4000
            6   C5a C    17.7800  -29.4000
            7   N1b N    16.5900  -28.7000
            8   C8y C    18.9700  -28.7000
            9   C8x C    20.1600  -29.4000
            10  C8y C    21.4200  -28.7000
            11  C8y C    21.4200  -27.3000
            12  C8y C    20.1600  -26.6000
            13  C8x C    18.9700  -27.3000
            14  O5a O    17.7800  -30.8000
            15  X   Cl   22.6100  -29.4000
            16  C2b C    22.6100  -26.5300
            17  C2c C    23.8000  -27.2300
            18  C6a C    24.9900  -26.5300
            19  O6a O    24.9900  -25.1300
            20  C8y C    12.6700  -31.8500
            21  C8x C    11.2700  -31.8500
            22  C8x C    10.5700  -33.0400
            23  C8x C    11.2700  -34.3000
            24  C8y C    12.6700  -34.3000
            25  C8y C    13.3700  -33.0400
            26  O2a O    14.7700  -33.0400
            27  C1a C    15.5400  -34.2300
            28  C1c C    13.3700  -35.4900
            29  C1a C    14.7700  -35.4900
            30  O2a O    12.6700  -36.6800
            31  C1b C    11.2700  -36.6800
            32  C1b C    10.5700  -37.8700
            33  C1b C     9.1700  -37.8700
            34  C1b C     8.4700  -39.0600
            35  C1b C     7.0700  -39.0600
            36  C1a C     6.3700  -40.2500
            37  X   Cl   20.1428  -25.2001
            38  C1a C    23.8000  -28.6300
            39  O6a O    26.2053  -27.2251
BOND        41
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 1
            5     1   5 2
            6     6   7 1
            7     3   7 1
            8     6   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    6  14 2
            16   10  15 1
            17   11  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21    1  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   20  25 1
            28   25  26 1
            29   26  27 1
            30   24  28 1
            31   28  29 1 #Down
            32   28  30 1
            33   30  31 1
            34   31  32 1
            35   32  33 1
            36   33  34 1
            37   34  35 1
            38   35  36 1
            39   12  37 1
            40   17  38 1
            41   18  39 1

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