| Entry |
|
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| Name |
Pitavastatin calcium hydrate (JP18);
Livalo (TN) |
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| Formula |
(C25H23FNO4)2. 5H2O. Ca
|
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| Exact mass |
970.3376
|
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| Mol weight |
971.06
|
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| Structure |
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| Simcomp |
|
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| Class |
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
|
|---|
| Remark |
| Therapeutic category: | 2189 |
| Product (DG01838): | D01862<JP/US> D10568<JP> D11092<US> |
| Product (mixture): | D12438<JP> |
|
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| Efficacy |
Antihyperlipidemic, HMG-CoA reductase inhibitor |
|---|
| Target |
|
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| Pathway |
| hsa00900 | Terpenoid backbone biosynthesis |
|
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C10 LIPID MODIFYING AGENTS
C10A LIPID MODIFYING AGENTS, PLAIN
C10AA HMG CoA reductase inhibitors
C10AA08 Pitavastatin
D10568 Pitavastatin calcium hydrate (JP18) <JP>
USP drug classification [BR:br08302]
Cardiovascular Agents
Dyslipidemics, HMG CoA Reductase Inhibitors
Pitavastatin
D10568 Pitavastatin calcium hydrate (JP18)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
218 Hyperlipidemia agents
2189 Others
D10568 Pitavastatin calcium hydrate (JP18)
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
DG01838 Pitavastatin
D10568 Pitavastatin calcium hydrate
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01838 Pitavastatin
D10568 Pitavastatin calcium hydrate
Drug classes [BR:br08332]
Cardiovascular agent
DG01946 Hypolipidemic agent
D10568 Pitavastatin calcium hydrate
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Dehydrogenases
HMGCR
D10568 Pitavastatin calcium hydrate (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D10568 Pitavastatin calcium hydrate
D10568 Pitavastatin calcium tablets
D10568 Pitavastatin calcium orally disintegrating tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10568
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
DG01838 Pitavastatin
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01838 Pitavastatin
|
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| Other DBs |
|
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| LinkDB |
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| KCF data |
ATOM 68
1 C8x C 6.9300 -11.5500
2 C8x C 6.9300 -12.9500
3 C8x C 8.1200 -13.6500
4 C8y C 9.3800 -12.9500
5 C8y C 9.3800 -11.5500
6 C8x C 8.1200 -10.8500
7 N5x N 10.5700 -13.6500
8 C8y C 11.7600 -12.9500
9 C8y C 11.7600 -11.5500
10 C8y C 10.5700 -10.8500
11 C8y C 10.5700 -9.4500
12 C8x C 11.7600 -8.7500
13 C8x C 11.7600 -7.3500
14 C8y C 10.5700 -6.6500
15 C8x C 9.3800 -7.3500
16 C8x C 9.3800 -8.7500
17 C2b C 12.9500 -10.8500
18 C2b C 14.1400 -11.5500
19 X F 10.5700 -5.2500
20 C1y C 12.9500 -13.6500
21 C1c C 15.3300 -10.8500
22 C1b C 16.5200 -11.5500
23 C1c C 17.7100 -10.8500
24 C1b C 18.9000 -11.5500
25 O1a O 15.3300 -9.4500
26 O1a O 17.7100 -9.4500
27 C6a C 20.0900 -10.8500
28 O6a O 21.2800 -11.5500 #-
29 O6a O 20.0900 -9.4500
30 C1x C 14.3500 -13.6500
31 C1x C 13.6500 -14.8400
32 Z Ca 24.9200 -11.6200 #+
33 O0 O 30.3100 -11.6900
34 C8x C 6.9300 -11.5500
35 C8x C 6.9300 -12.9500
36 C8x C 8.1200 -13.6500
37 C8y C 9.3800 -12.9500
38 C8y C 9.3800 -11.5500
39 C8x C 8.1200 -10.8500
40 C8y C 10.5700 -10.8500
41 C8y C 11.7600 -11.5500
42 C8y C 11.7600 -12.9500
43 N5x N 10.5700 -13.6500
44 C1y C 12.9500 -13.6500
45 C1x C 13.6500 -14.8400
46 C1x C 14.3500 -13.6500
47 C2b C 12.9500 -10.8500
48 C2b C 14.1400 -11.5500
49 C1c C 15.3300 -10.8500
50 C1b C 16.5200 -11.5500
51 C1c C 17.7100 -10.8500
52 C1b C 18.9000 -11.5500
53 C6a C 20.0900 -10.8500
54 O6a O 21.2800 -11.5500 #-
55 O6a O 20.0900 -9.4500
56 O1a O 17.7100 -9.4500
57 O1a O 15.3300 -9.4500
58 C8y C 10.5700 -9.4500
59 C8x C 11.7600 -8.7500
60 C8x C 11.7600 -7.3500
61 C8y C 10.5700 -6.6500
62 C8x C 9.3800 -7.3500
63 C8x C 9.3800 -8.7500
64 X F 10.5700 -5.2500
65 O0 O 30.3100 -11.6900
66 O0 O 30.3100 -11.6900
67 O0 O 30.3100 -11.6900
68 O0 O 30.3100 -11.6900
BOND 68
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 5 10 1
12 10 11 1
13 11 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 15 16 2
18 11 16 1
19 9 17 1
20 17 18 2
21 14 19 1
22 8 20 1
23 18 21 1
24 21 22 1
25 22 23 1
26 23 24 1
27 21 25 1 #Up
28 23 26 1 #Up
29 24 27 1
30 27 28 1
31 27 29 2
32 31 30 1
33 31 20 1
34 20 30 1
35 34 35 2
36 35 36 1
37 36 37 2
38 37 38 1
39 38 39 2
40 34 39 1
41 37 43 1
42 43 42 2
43 42 41 1
44 41 40 2
45 38 40 1
46 40 58 1
47 58 59 2
48 59 60 1
49 60 61 2
50 61 62 1
51 62 63 2
52 58 63 1
53 41 47 1
54 47 48 2
55 61 64 1
56 42 44 1
57 48 49 1
58 49 50 1
59 50 51 1
60 51 52 1
61 49 57 1 #Up
62 51 56 1 #Up
63 52 53 1
64 53 54 1
65 53 55 2
66 45 46 1
67 45 44 1
68 44 46 1
BRACKET 1 5.9500 -15.1900 5.9500 -4.1300
1 22.4700 -4.1300 22.4700 -15.1900
1 2
ORIGINAL 1 1 2 3 4 5 6 10 9 8 7 20 31 30 17 18 21
1 22 23 24 27 28 29 26 25 11 12 13 14 15 16 19
REPEAT 1 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49
1 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64
2 28.0000 -12.5300 28.0000 -10.7800
2 30.9400 -10.7800 30.9400 -12.5300
2 5
ORIGINAL 2 33
REPEAT 2 65 66 67 68
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