KEGG   DRUG: Sodium zirconium cyclosilicate
Entry
D10727                      Drug                                   
Name
Sodium zirconium cyclosilicate (USAN);
Sodium zirconium cyclosilicate hydrate (JAN);
Lokelma (TN)
Product
LOKELMA (A-S Medication Solutions), LOKELMA (A-S Medication Solutions), LOKELMA (AstraZeneca Pharmaceuticals LP)
Formula
ZrH4O6. 3H4SiO4. 2H2O. 2Na
Exact mass
559.8698
Mol weight
561.6068
Structure
Remark
Therapeutic category: 2190
ATC code: V03AE10
Product: D10727<JP/US>
Efficacy
Antihyperkalemic, Potassium lowering agent
Comment
selective cation exchanger
Treatment of hyperkalemia
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AE Drugs for treatment of hyperkalemia and hyperphosphatemia
     V03AE10 Sodium zirconium cyclosilicate
      D10727  Sodium zirconium cyclosilicate (USAN) <JP/US>
USP drug classification [BR:br08302]
 Electrolytes/Minerals/Metals/Vitamins
  Potassium Binders
   Sodium Zirconium Cyclosilicate
    D10727  Sodium zirconium cyclosilicate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D10727  Sodium zirconium cyclosilicate (USAN); Sodium zirconium cyclosilicate hydrate (JAN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10727
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10727
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10727
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10727
Other DBs
CAS: 242800-27-7
PubChem: 254741688
LinkDB
KCF data

ATOM        26
            1   Z   Si   15.2121  -14.7857
            2   O1a O    15.2121  -13.4041
            3   O1a O    15.2121  -16.1673
            4   O1a O    16.5937  -14.7857
            5   O1a O    13.8306  -14.7857
            6   Z   Zr   22.8109  -14.5785
            7   O1a O    23.5016  -13.3820
            8   O1a O    22.1201  -13.3820 #-
            9   O1a O    21.4293  -14.5785
            10  O1a O    24.1924  -14.5785
            11  O1a O    21.9721  -15.9007
            12  O1a O    23.5016  -15.7749 #-
            13  O0  O    23.7770  -18.7306
            14  Z   Na   21.6300  -11.8300 #+
            15  Z   Na   24.5700  -16.5900 #+
            16  Z   Si   15.2121  -14.7857
            17  O1a O    15.2121  -13.4041
            18  O1a O    15.2121  -16.1673
            19  O1a O    16.5937  -14.7857
            20  O1a O    13.8306  -14.7857
            21  Z   Si   15.2121  -14.7857
            22  O1a O    15.2121  -13.4041
            23  O1a O    15.2121  -16.1673
            24  O1a O    16.5937  -14.7857
            25  O1a O    13.8306  -14.7857
            26  O0  O    23.7770  -18.7306
BOND        18
            1     6   7 1
            2     6   8 1
            3     6   9 1
            4     6  10 1
            5     6  11 1
            6     6  12 1
            7     1   2 1
            8     1   3 1
            9     1   4 1
            10    1   5 1
            11   16  17 1
            12   16  18 1
            13   16  19 1
            14   16  20 1
            15   21  22 1
            16   21  23 1
            17   21  24 1
            18   21  25 1
BRACKET     1    12.6700  -16.5900   12.6700  -12.6700
            1    17.7800  -12.6700   17.7800  -16.5900
            1  3
 ORIGINAL  1    1   2   3   4   5
 REPEAT    1   16  17  18  19  20  21  22  23  24  25
            2    22.1200  -19.6700   22.1200  -18.0600
            2    24.2900  -18.0600   24.2900  -19.6700
            2  2
 ORIGINAL  2   13
 REPEAT    2   26

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