KEGG   DRUG: Tiotropium and olodaterol
Entry
D10744            Mixture   Drug                                   
Name
Tiotropium and olodaterol;
Spiolto (TN);
Stiolto respimat (TN)
Product
STIOLTO RESPIMAT (Boehringer Ingelheim Pharmaceuticals)
Component
Tiotropium bromide hydrate [DR:D01929], (Olodaterol hydrochloride [DR:D10020] | Olodaterol [DR:D10145])
Class
Metabolizing enzyme substrate
 DG02924  UGT substrate
Remark
Therapeutic category: 2259
ATC code: R03AL06 R03BB54
Product: D10744<JP/US>
Efficacy
Bronchodilator
  Disease
Chronic obstructive pulmonary disease [DS:H01714]
Comment
Olodaterol is eliminated by glucuronidation and O-demethylation.
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AL Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
     R03AL06 Olodaterol and tiotropium bromide
      D10744  Tiotropium and olodaterol <JP/US>
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BB Anticholinergics
     R03BB54 Tiotropium bromide, combinations
      D10744  Tiotropium and olodaterol <JP/US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilator Combinations
   Tiotropium Bromide/ Olodaterol
    D10744  Tiotropium and olodaterol
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   225  Bronchodilators
    2259  Others
     D10744  Tiotropium and olodaterol
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   D10744  Tiotropium and olodaterol
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10744
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10744
Other DBs
PubChem: 254741705
LinkDB

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