KEGG   DRUG: Vonoprazan, amoxicillin and metronidazole
Entry
D10774            Mixture   Drug                                   
Name
Vonoprazan, amoxicillin and metronidazole;
Vonopion (TN)
Component
Vonoprazan fumarate [DR:D10466], (Amoxicillin hydrate [DR:D00229] | Amoxicillin [DR:D07452]), Metronidazole [DR:D00409]
Class
Metabolizing enzyme substrate
 DG02919  CYP2B6 substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 6199
ATC code: A02BD15
Product: D10774<JP>
Efficacy
Antibacterial
Comment
Vonoprazan is metabolized by CYP3A4 with some contribution from CYP2B6, CYP2C19 and CYP2D6.
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2B6 [HSA:1555], CYP2C19 [HSA:1557], CYP2D6 [HSA:1565]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BD Combinations for eradication of Helicobacter pylori
     A02BD15 Vonoprazan, amoxicillin and metronidazole
      D10774  Vonoprazan, amoxicillin and metronidazole <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   619  Miscellaneous
    6199  Miscellaneous
     D10774  Vonoprazan, amoxicillin and metronidazole
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02919  CYP2B6 substrate
   D10774  Vonoprazan, amoxicillin and metronidazole
  DG01639  CYP2C19 substrate
   D10774  Vonoprazan, amoxicillin and metronidazole
  DG01644  CYP2D6 substrate
   D10774  Vonoprazan, amoxicillin and metronidazole
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D10774  Vonoprazan, amoxicillin and metronidazole
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Combination for eradication of H. pylori
    D10774  Vonoprazan, amoxicillin and metronidazole <JP>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10774
Other DBs
PubChem: 313046632
LinkDB

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