| Entry |
|
|---|
| Name |
Fentanyl hydrochloride (JAN);
Ionsys (TN) |
|---|
| Formula |
C22H28N2O. HCl
|
|---|
| Exact mass |
372.1968
|
|---|
| Mol weight |
372.9315
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG02030 Anesthetics
DG02027 General anesthetics
DG02026 Opioid anesthetics
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
Analgesic
DG01984 Opioid analgesics
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00791): | D00320<JP/US> D01399<JP/US> |
|
|---|
| Efficacy |
Analgesic (narcotic), Opioid receptor agonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N01 ANESTHETICS
N01A ANESTHETICS, GENERAL
N01AH Opioid anesthetics
N01AH01 Fentanyl
D10811 Fentanyl hydrochloride (JAN)
N02 ANALGESICS
N02A OPIOIDS
N02AB Phenylpiperidine derivatives
N02AB03 Fentanyl
D10811 Fentanyl hydrochloride (JAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG02030 Anesthetics
DG02027 General anesthetics
DG02026 Opioid anesthetics
DG00791 Fentanyl
D10811 Fentanyl hydrochloride
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00791 Fentanyl
D10811 Fentanyl hydrochloride
Analgesic
DG01984 Opioid analgesics
DG00791 Fentanyl
D10811 Fentanyl hydrochloride
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00791 Fentanyl
D10811 Fentanyl hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D10811 Fentanyl hydrochloride (JAN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D10811
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10811
Drug groups [BR:br08330]
Neuropsychiatric agent
DG02030 Anesthetics
DG02027 General anesthetics
DG02026 Opioid anesthetics
DG00791 Fentanyl
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00791 Fentanyl
Analgesic
DG01984 Opioid analgesics
DG00791 Fentanyl
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00791 Fentanyl
|
|---|
| Other DBs |
|
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| LinkDB |
|
|---|
| KCF data |
ATOM 26
1 N1c N 15.6081 -14.7682
2 C1y C 16.8680 -15.4682
3 C8y C 14.4183 -15.4682
4 C5a C 15.6081 -13.3684
5 C1x C 16.8680 -16.8680
6 C1x C 18.0579 -14.7682
7 C8x C 13.2284 -14.7682
8 C8x C 14.4183 -16.8680
9 C1b C 16.8680 -12.6685
10 O5a O 14.4183 -12.6685
11 C1x C 18.0579 -17.5679
12 C1x C 19.2477 -15.4682
13 C8x C 11.9686 -15.4682
14 C8x C 13.1584 -17.5679
15 C1a C 18.0579 -13.3684
16 N1y N 19.2477 -16.8680
17 C8x C 11.9686 -16.7980
18 C1b C 20.5076 -17.5679
19 C1b C 21.6974 -16.8680
20 C8y C 22.8873 -17.5679
21 C8x C 22.8873 -18.9677
22 C8x C 24.1471 -16.8680
23 C8x C 24.1471 -19.6677
24 C8x C 25.3370 -17.5679
25 C8x C 25.3370 -18.9677
26 X Cl 24.5000 -13.7900
BOND 27
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 4 10 2
10 5 11 1
11 6 12 1
12 7 13 1
13 8 14 2
14 9 15 1
15 11 16 1
16 13 17 2
17 16 18 1
18 18 19 1
19 19 20 1
20 20 21 1
21 20 22 2
22 21 23 2
23 22 24 1
24 23 25 1
25 12 16 1
26 14 17 1
27 24 25 2
|
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