KEGG   DRUG: Bexagliflozin
Entry
D10865                      Drug                                   
Name
Bexagliflozin (USAN);
Brenzavvy (TN)
Product
BRENZAVVY (TheracosBio)
  Generic
BEXAGLIFLOZIN (TheracosBio)
Formula
C24H29ClO7
Exact mass
464.1602
Mol weight
464.9359
Structure
Simcomp
Class
Antidiabetic agent
 DG02044  Hypoglycemic agent
  DG01794  SGLT2 inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
 DG02924  UGT substrate
  DG03188  UGT1A9 substrate
Remark
ATC code: A10BK08
Product: D10865<US>
Efficacy
Antidiabetic, SGLT-2 inhibitor
  Disease
Type 2 diabetes mellitus [DS:H00409]
Target
SLC5A2 (SGLT2) [HSA:6524] [KO:K14382]
Metabolism
Enzyme: UGT1A9 [HSA:54600]; CYP3A [HSA:1576 1577 1551]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors
     A10BK08 Bexagliflozin
      D10865  Bexagliflozin (USAN) <US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Sodium-Glucose Co-Transporter 2 (SGLT2) Inhbitor
    Bexagliflozin
     D10865  Bexagliflozin (USAN)
Drug groups [BR:br08330]
 Antidiabetic agent
  DG02044  Hypoglycemic agent
   DG01794  SGLT2 inhibitor
    D10865  Bexagliflozin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D10865  Bexagliflozin
  DG02924  UGT substrate
   DG03188  UGT1A9 substrate
    D10865  Bexagliflozin
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC5
    SLC5A2 (SGLT2)
     D10865  Bexagliflozin (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10865
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10865
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10865
Other DBs
CAS: 1118567-05-7
PubChem: 319902665
ChEBI: 229225
LinkDB
KCF data

ATOM        32
            1   C1y C     6.8600  -16.0300
            2   O2x O     6.8600  -14.6300
            3   C1y C     5.6700  -13.9300
            4   C1y C     4.4100  -14.6300
            5   C1y C     4.4100  -16.0300
            6   C1y C     5.6700  -16.7300
            7   O1a O     5.6700  -18.1300
            8   O1a O     3.2200  -13.9300
            9   O1a O     3.2200  -16.7300
            10  C1b C     5.6700  -12.5300
            11  C8y C     8.0500  -16.7300
            12  C8x C     8.0500  -18.1300
            13  C8x C     9.3100  -18.8300
            14  C8y C    10.5000  -18.1300
            15  C8y C    10.5000  -16.7300
            16  C8x C     9.3100  -16.0300
            17  X   Cl   11.6900  -18.8300
            18  C1b C    11.6900  -16.0300
            19  C8y C    12.8800  -16.7300
            20  C8x C    12.8800  -18.1300
            21  C8x C    14.1400  -18.8300
            22  C8y C    15.3300  -18.1300
            23  C8x C    15.3300  -16.7300
            24  C8x C    14.1400  -16.0300
            25  O2a O    16.5200  -18.8300
            26  C1b C    17.7100  -18.1300
            27  C1b C    18.9000  -18.8300
            28  O2a O    20.0900  -18.1300
            29  C1y C    21.2800  -18.8300
            30  C1x C    22.6800  -18.8300
            31  C1x C    21.9800  -20.0200
            32  O1a O     6.8600  -11.8300
BOND        35
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     6   7 1 #Down
            8     4   8 1 #Down
            9     5   9 1 #Up
            10    3  10 1 #Up
            11    1  11 1 #Up
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   11  16 1
            18   14  17 1
            19   15  18 1
            20   18  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   19  24 1
            27   22  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 1
            31   28  29 1
            32   30  29 1
            33   31  30 1
            34   29  31 1
            35   10  32 1

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