Entry |
|
Name |
Levoketoconazole (USAN/INN); Recorlev (TN) |
Product |
|
Formula |
C26H28Cl2N4O4
|
Exact mass |
530.1488
|
Mol weight |
531.4309
|
Structure |
|
Simcomp |
|
Remark |
|
Efficacy |
Cortisol and testosterone synthesis inhibitor |
Disease |
Cushing's syndrome [DS: H01431] |
Comment |
Treatment of Cushing's syndrome
|
Target |
|
Pathway |
hsa04927 | Cortisol synthesis and secretion |
|
Network |
nt06310 | CRH-ACTH-cortisol signaling |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02C ANTIADRENAL PREPARATIONS
H02CA Anticorticosteroids
H02CA04 Levoketoconazole
D10950 Levoketoconazole (USAN/INN) <US>
USP drug classification [BR:br08302]
Hormonal Agents, Suppressant (Pituitary)
Levoketoconazole
D10950 Levoketoconazole (USAN/INN)
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Cytochrome P450
CYP17A1
D10950 Levoketoconazole (USAN/INN) <US>
CYP11B1
D10950 Levoketoconazole (USAN/INN) <US>
CYP11A1
D10950 Levoketoconazole (USAN/INN) <US>
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 36
1 C1z C 13.5284 -16.2089
2 C8y C 12.3295 -15.5188
3 O2x O 13.9555 -17.5248
4 C1b C 12.4933 -17.1155
5 O2x O 14.6515 -15.3900
6 C8y C 12.3295 -14.1325
7 C8x C 11.1304 -16.2089
8 C1y C 15.3417 -17.5248
9 N4y N 11.0429 -17.1212
10 C1x C 15.7802 -16.2089
11 C8x C 11.1304 -13.4424
12 X Cl 13.5284 -13.4424
13 C8x C 9.9315 -15.5188
14 C1b C 16.7628 -18.2968
15 C8x C 9.9140 -16.3025
16 C8x C 10.6100 -18.4372
17 C8y C 9.9315 -14.1325
18 O2a O 18.1256 -17.3669
19 C8x C 8.7911 -17.1212
20 N5x N 9.2238 -18.4372
21 X Cl 8.7327 -13.4424
22 C8y C 19.5177 -17.3728
23 C8x C 20.2078 -18.5775
24 C8x C 20.2195 -16.1737
25 C8x C 21.5939 -18.5834
26 C8x C 21.5998 -16.1795
27 C8y C 22.2899 -17.3786
28 N1y N 23.6701 -17.3845
29 C1x C 24.3602 -18.5892
30 C1x C 24.3662 -16.1912
31 C1x C 25.7465 -18.5951
32 C1x C 25.7523 -16.1912
33 N1y N 26.4424 -17.3903
34 C5a C 27.8287 -17.3262
35 C1a C 28.5129 -18.6009
36 O5a O 28.5246 -16.2029
BOND 40
1 1 2 1 #Down
2 1 3 1
3 1 4 1 #Up
4 1 5 1
5 2 6 1
6 2 7 2
7 3 8 1
8 4 9 1
9 5 10 1
10 6 11 2
11 6 12 1
12 7 13 1
13 8 14 1 #Up
14 9 15 1
15 9 16 1
16 11 17 1
17 14 18 1
18 15 19 2
19 16 20 2
20 17 21 1
21 18 22 1
22 22 23 2
23 22 24 1
24 23 25 1
25 24 26 2
26 25 27 2
27 27 28 1
28 28 29 1
29 28 30 1
30 29 31 1
31 30 32 1
32 31 33 1
33 33 34 1
34 34 35 1
35 34 36 2
36 8 10 1
37 13 17 2
38 19 20 1
39 26 27 1
40 32 33 1
|