| Entry |
|
|---|
| Name |
Omidenepag (USAN/INN) |
|---|
| Formula |
C23H22N6O4S
|
|---|
| Exact mass |
478.1423
|
|---|
| Mol weight |
478.5236
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
Metabolizing enzyme substrate
DG02970 CES substrate
DG03241 CES1 substrate
|
|---|
| Remark |
| Product (DG02831): | D10966<JP/US> |
|
|---|
| Efficacy |
Antiglaucoma, Prostaglandin E2 receptor agonist |
|---|
| Comment |
Treatment of open-angle glaucoma and ocular hypertension
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EX Other antiglaucoma preparations
S01EX06 Omidenepag
D10965 Omidenepag (USAN/INN)
Drug groups [BR:br08330]
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG02831 Omidenepag
D10965 Omidenepag
Metabolizing enzyme substrate
DG02970 CES substrate
DG03241 CES1 substrate
DG02831 Omidenepag
D10965 Omidenepag
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Prostaglandin
PTGER2
D10965 Omidenepag (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10965
Drug groups [BR:br08330]
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG02831 Omidenepag
Metabolizing enzyme substrate
DG02970 CES substrate
DG03241 CES1 substrate
DG02831 Omidenepag
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 34
1 C8x C 13.9307 -13.0205
2 C8x C 13.9307 -14.4206
3 C8y C 15.1432 -15.1206
4 N5x N 16.3558 -14.4206
5 C8y C 16.3558 -13.0205
6 C8x C 15.1432 -12.3205
7 C1b C 15.1432 -16.5205
8 N1c N 16.3389 -17.2110
9 C1b C 17.5261 -16.5255
10 S4a S 16.3391 -18.6205
11 C8y C 18.7176 -17.2136
12 C8x C 18.7176 -18.6205
13 C8x C 19.9301 -19.3206
14 C8y C 21.1427 -18.6205
15 C8x C 21.1427 -17.2135
16 C8x C 19.9301 -16.5134
17 N4y N 22.3541 -19.3200
18 C8x C 22.5003 -20.7108
19 C8x C 23.8681 -21.0015
20 C8x C 24.5674 -19.7904
21 N5x N 23.6316 -18.7513
22 C8y C 15.1055 -19.3331
23 C8x C 13.8992 -18.6368
24 N5x N 12.6867 -19.3371
25 C8x C 12.6869 -20.7372
26 C8x C 13.8932 -21.4334
27 C8x C 15.1057 -20.7332
28 N1b N 17.5933 -12.3205
29 C1b C 18.8059 -13.0205
30 C6a C 20.0184 -12.3205
31 O6a O 21.2309 -13.0205
32 O6a O 20.0184 -10.9204
33 O3c O 17.7391 -18.6205
34 O3c O 17.0391 -19.8331
BOND 37
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 3 7 1
8 7 8 1
9 8 9 1
10 8 10 1
11 9 11 1
12 11 12 2
13 12 13 1
14 13 14 2
15 14 15 1
16 15 16 2
17 11 16 1
18 14 17 1
19 17 18 1
20 18 19 2
21 19 20 1
22 20 21 2
23 17 21 1
24 10 22 1
25 22 23 2
26 23 24 1
27 24 25 2
28 25 26 1
29 26 27 2
30 22 27 1
31 5 28 1
32 28 29 1
33 29 30 1
34 30 31 1
35 30 32 2
36 10 33 2
37 10 34 2
|
|---|
