| Entry |
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| Name |
Mirtazapine hydrate (JAN) |
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| Formula |
C17H19N3. xH2O
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
Neuropsychiatric agent
DG01729 Tetracyclic antidepressant
DG03077 Noradrenergic and specific serotonergic antidepressant (NaSSA)
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Product (DG02838): | D00563<JP/US> |
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| Efficacy |
Antidepressant, Serotonin receptor antagonist |
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AX Other antidepressants
N06AX11 Mirtazapine
D11056 Mirtazapine hydrate (JAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
DG02838 Mirtazapine
D11056 Mirtazapine hydrate
Neuropsychiatric agent
DG01729 Tetracyclic antidepressant
DG02838 Mirtazapine
D11056 Mirtazapine hydrate
DG03077 Noradrenergic and specific serotonergic antidepressant (NaSSA)
DG02838 Mirtazapine
D11056 Mirtazapine hydrate
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG02838 Mirtazapine
D11056 Mirtazapine hydrate
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG02838 Mirtazapine
D11056 Mirtazapine hydrate
DG01644 CYP2D6 substrate
DG02838 Mirtazapine
D11056 Mirtazapine hydrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02838 Mirtazapine
D11056 Mirtazapine hydrate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA2
D11056 Mirtazapine hydrate (JAN)
Serotonin
HTR2
D11056 Mirtazapine hydrate (JAN)
Ion channels
Ligand-gated ion channels
Serotonin
HTR3
D11056 Mirtazapine hydrate (JAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D11056
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01460 alpha2-Adrenergic receptor antagonist
DG02838 Mirtazapine
Neuropsychiatric agent
DG01729 Tetracyclic antidepressant
DG02838 Mirtazapine
DG03077 Noradrenergic and specific serotonergic antidepressant (NaSSA)
DG02838 Mirtazapine
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG02838 Mirtazapine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG02838 Mirtazapine
DG01644 CYP2D6 substrate
DG02838 Mirtazapine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02838 Mirtazapine
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 21
1 C1y C 17.9614 -15.9896
2 N1y N 19.3701 -15.9896
3 C8y C 20.2153 -14.9331
4 C8y C 19.9336 -13.5244
5 C8y C 17.1162 -14.9331
6 C1x C 18.6657 -12.9609
7 C8y C 17.3979 -13.5244
8 C8x C 15.7779 -15.3557
9 C8x C 14.7214 -14.3696
10 C8x C 15.0031 -13.0314
11 C8x C 16.3414 -12.6087
12 C8x C 20.9197 -12.6087
13 C8x C 22.2579 -13.0314
14 C8x C 22.6101 -14.3696
15 N5x N 21.5536 -15.2853
16 C1x C 20.0744 -17.1870
17 C1x C 19.3701 -18.4549
18 N1y N 18.0318 -18.4549
19 C1x C 17.2570 -17.2575
20 C1a C 17.3275 -19.7227
21 O0 O 24.8500 -18.7600
BOND 23
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 2
6 1 2 1
7 6 7 1
8 5 8 1
9 8 9 2
10 9 10 1
11 10 11 2
12 7 11 1
13 4 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 3 15 2
18 2 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 1 19 1
23 18 20 1
BRACKET 1 22.7500 -19.5300 22.7500 -17.6400
1 25.6200 -17.6400 25.6200 -19.5300
1 x
ORIGINAL 1 21
REPEAT 1
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