KEGG   DRUG: Ertugliflozin and sitagliptin
Entry
D11066            Mixture   Drug                                   
Name
Ertugliflozin and sitagliptin;
Steglujan (TN)
Product
STEGLUJAN (Merck Sharp & Dohme LLC)
Component
(Ertugliflozin pidolate [DR:D11043] | Ertugliflozin [DR:D10313]), (Sitagliptin phosphate [DR:D06645] | Sitagliptin [DR:D08516] | Sitagliptin phosphate [DR:D12294])
Class
Antidiabetic agent
 DG02044  Hypoglycemic agent
  DG03035  Combination of DPP-4 inhibitor and SGLT2 inhibitor
Metabolizing enzyme substrate
 DG02924  UGT substrate
  DG03188  UGT1A9 substrate
  DG03190  UGT2B7 substrate
Remark
ATC code: A10BD24
Product: D11066<US>
Efficacy
Antidiabetic
  Disease
Type 2 diabetes mellitus [DS:H00409]
Comment
Ertugliflozin is primarily metabolized by UGT1A9 and UGT2B7.
Metabolism
Enzyme: UGT1A9 [HSA:54600], UGT2B7 [HSA:7364]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BD Combinations of oral blood glucose lowering drugs
     A10BD24 Sitagliptin and ertugliflozin
      D11066  Ertugliflozin and sitagliptin <US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Combinations
   Ertugliflozin/ Sitagliptin
    D11066  Ertugliflozin and sitagliptin
Drug groups [BR:br08330]
 Antidiabetic agent
  DG02044  Hypoglycemic agent
   DG03035  Combination of DPP-4 inhibitor and SGLT2 inhibitor
    D11066  Ertugliflozin and sitagliptin
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG03188  UGT1A9 substrate
    D11066  Ertugliflozin and sitagliptin
   DG03190  UGT2B7 substrate
    D11066  Ertugliflozin and sitagliptin
Drug classes [BR:br08332]
 Antidiabetic agent
  DG02044  Hypoglycemic agent
   D11066  Ertugliflozin and sitagliptin
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11066
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11066
Other DBs
PubChem: 375581013
LinkDB

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